[RASMB] Biophysical research associate position open at Genentech

[Tony Giannetti]

Greetings everyone,
I have a position open for a research associate, non-Ph.D. level, in my
group at Genentech working in small-molecule SPR (Biacore) to support
fragment screening, SAR by binding, HTS hit triage, as well as biological
and technical research.  I'm wondering if you might be able to forward this
on to individuals you think may be interested.

People with SPR experience, and especially small-molecule SPR experience,
are rare in the world at the moment so that skill is by no means required,
though appreciated.  In that vein I'm looking for someone experienced with
any other of a variety of biophysical techniques, has spent a fair amount of
time doing data analysis and dose-response curve fitting, such as IC50 data,
and has industrial experience working and presenting to project teams.
 People experienced and/or talented with more analytical/physical approaches
are excellent at learning SPR as evidenced by people I've already trained.

The successful candidate will be working with me and a more junior RA with
significant SPR experience.

People from outside the Bay Area are very welcome to apply as well.

Job description is posted below and can also be found at:

http://jobpostings.gene.com/pljb/Genentech/external/applicant/index.jsp

and found using the posting code:  1000031876

Please feel free to forward this on and thanks for the help.  All the best,
Tony


Responsibilities:
We have an opening for a talented Research Associate or Sr. Research
Associate to join the Biochemical Pharmacology group in the Small
Molecules Drug Discovery Division in South San Francisco.  The successful
candidate will be responsible for developing, optimizing,
validating, and executing Surface Plasmon Resonance (SPR as implemented with
Biacore technology) assays that monitor direct
binding of small molecules to protein targets.  Primary use will be for
screening fragments (low molecular weight low affinity binders) in support
of lead discovery activities, HTS hit validation, and routine SAR of
advancing chemical series.  Occasionally there will be detailed binding
characterization for late lead-optimization
programs, and albumin and alpha-1-acid glycoprotein binding studies for late
stage or clinical programs. Thus, candidates will have
broad exposure to drug discovery and development.

The successful candidate will also have opportunities to help develop
innovative SPR methods and applications, and apply SPR and
other biophysical techniques within multi-disciplinary drug discovery
project teams.  Close collaboration with the NMR group that is conducting
complementary fragment screening will be key to success, as will
collaboration with the HTS group, structural biology, medicinal chemistry,
and pathway cell biology experts.

Requirements:
A B.S. in biochemistry, chemistry, biophysics, or closely related field is
required with at least 3+ years doing quantitative or analytical work in an
industrial environment.  The candidate should
have experience with protein characterization and modification, as well as a
solid foundation in analyzing binding or IC50 data.  Some direct experience
with SPR is preferred but not required.  Experience with enzymology,
biophysical techniques (mass spec, NMR,
ITC, flow cytometry, light scattering, or other direct-binding platforms
such as ForteBio, Fujifilm, Proteon, etc.), performed in a
high throughput environment, and a desire to develop new skills will  be key
to success. Experience with robotic liquid handling and
assay automation is beneficial but not required.

Strong teamwork, organizational skills, and written and oral communication
skills, and fluidity with Office applications, especially Excel, are
essential.


DIVISION:  Research (gRED)
REQUISITION NUMBER:  10-1000031876 RA/SRA BPH SME
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