<div class="gmail_quote">Greetings everyone,<div>I have a position open for a research associate, non-Ph.D. level, in my group at Genentech working in small-molecule SPR (Biacore) to support fragment screening, SAR by binding, HTS hit triage, as well as biological and technical research. I'm wondering if you might be able to forward this on to individuals you think may be interested.</div>
<div><br></div><div>People with SPR experience, and especially small-molecule SPR experience, are rare in the world at the moment so that skill is by no means required, though appreciated. In that vein I'm looking for someone experienced with any other of a variety of biophysical techniques, has spent a fair amount of time doing data analysis and dose-response curve fitting, such as IC50 data, and has industrial experience working and presenting to project teams. People experienced and/or talented with more analytical/physical approaches are excellent at learning SPR as evidenced by people I've already trained.</div>
<div><br></div><div>The successful candidate will be working with me and a more junior RA with significant SPR experience.</div><div><br></div><div>People from outside the Bay Area are very welcome to apply as well.</div>
<div><br></div><div>Job description is posted below and can also be found at:</div><div><br></div><div><a href="http://jobpostings.gene.com/pljb/Genentech/external/applicant/index.jsp" target="_blank">http://jobpostings.gene.com/pljb/Genentech/external/applicant/index.jsp</a></div>
<div><br></div><div>and found using the posting code: <span style="font-family:Verdana, Arial, sans-serif;font-size:11px">1000031876 </span></div>
<div><br></div><div>Please feel free to forward this on and thanks for the help. All the best,</div><div>Tony</div><div><br></div><div><br></div><div><span style="font-family:Verdana, Arial, sans-serif;font-size:11px">Responsibilities: <br>
We have an opening for a talented Research Associate or Sr. Research Associate to join the Biochemical Pharmacology group in the Small <br>Molecules Drug Discovery Division in South San Francisco. The successful candidate will be responsible for developing, optimizing, <br>
validating, and executing Surface Plasmon Resonance (SPR as implemented with Biacore technology) assays that monitor direct <br>binding of small molecules to protein targets. Primary use will be for screening fragments (low molecular weight low affinity binders) in support of lead discovery activities, HTS hit validation, and routine SAR of advancing chemical series. Occasionally there will be detailed binding characterization for late lead-optimization <br>
programs, and albumin and alpha-1-acid glycoprotein binding studies for late stage or clinical programs. Thus, candidates will have <br>broad exposure to drug discovery and development. <br><br>The successful candidate will also have opportunities to help develop innovative SPR methods and applications, and apply SPR and <br>
other biophysical techniques within multi-disciplinary drug discovery project teams. Close collaboration with the NMR group that is conducting complementary fragment screening will be key to success, as will collaboration with the HTS group, structural biology, medicinal chemistry, and pathway cell biology experts. <br>
<br>Requirements: <br>A B.S. in biochemistry, chemistry, biophysics, or closely related field is required with at least 3+ years doing quantitative or analytical work in an industrial environment. The candidate should <br>
have experience with protein characterization and modification, as well as a solid foundation in analyzing binding or IC50 data. Some direct experience with SPR is preferred but not required. Experience with enzymology, biophysical techniques (mass spec, NMR, <br>
ITC, flow cytometry, light scattering, or other direct-binding platforms such as ForteBio, Fujifilm, Proteon, etc.), performed in a <br>high throughput environment, and a desire to develop new skills will be key to success. Experience with robotic liquid handling and <br>
assay automation is beneficial but not required. <br><br>Strong teamwork, organizational skills, and written and oral communication skills, and fluidity with Office applications, especially Excel, are essential.<br><br><br>
DIVISION: Research (gRED)<br>REQUISITION NUMBER: 10-1000031876 RA/SRA BPH SME</span></div>
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