[RASMB] analysis of biotech samples [was: non-ideality in SV]

[Arthur Rowe]

And just a very little response, Jack! We do get some extremely interesting
samples to work on in the NCMH Business Centre, and obviously where
appropriate we can, for our own satisfaction and benefit*, pursue analysis
with all the rigour we can summon up, whether the ultimate client actually
wants it doing or not.

But the image of our sitting down for a cosy chat and earnest scientific
discussion with the said client's research director is not always quite
where it is at. More often we are recruited by an agency, whose expertise is
in finding analytical services which meet a client company's needs. And
beyond that, the agency may itself have been recruited by agency which
specialises in recruiting agencies! A system which, whilst it sounds
hilarious, actually is not without certain advantages.

Regards

Arthur

*challenging samples supplied under CDAs by clients can be the basis for
extending one's capabilities and methodologies. OK - you cannot publish what
you have done with a client's sample. But a new approach which worked well
CAN be applied to systems which you are working on in a 'pure research'
context. And then of course published. Been there - done that. A.



Just though I would add a little to this thread:

(4) I agree with Arthur that to date most biotech companies have not been
terribly interested in reversible association thermodynamics. This is
probably going to change at least somewhat due to (3) above.
I have worked with  a number of companies on drugs that interact with
tubulin and in each case I was allowed to pursue the full thermodynamic
analysis of the AUC data.  It has a lot to do with how you sell it to them,
who their research director is, and how successful you are at convincing
readers, reviewers and the company the data has predictive value.  Good data
and rigorous analysis is never a bad idea, even if companies are focused on
their bottom line.


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Dr. John J. "Jack" Correia
Department of Biochemistry
University of Mississippi Medical Center
2500 North State Street
Jackson, MS  39216
(601) 984-1522     
fax (601) 984-1501 
email address: jcorreia at biochem.umsmed.edu
homepage location: http://biochemistry.umc.edu/correia.html
dept homepage location:    http://biochemistry.umc.edu/
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