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<TITLE>Re: [RASMB] analysis of biotech samples [was: non-ideality in SV]</TITLE>
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<BLOCKQUOTE><FONT COLOR="#800000">And just a very little response, Jack! We do get some extremely interesting samples to work on in the NCMH Business Centre, and obviously where appropriate we can, for our own satisfaction and benefit*, pursue analysis with all the rigour we can summon up, whether the ultimate client actually wants it doing or not.<BR>
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But the image of our sitting down for a cosy chat and earnest scientific discussion with the said client's research director is not always quite where it is at. More often we are recruited by an agency, whose expertise is in finding analytical services which meet a client company's needs. And beyond that, the agency may itself have been recruited by agency which specialises in recruiting agencies! A system which, whilst it sounds hilarious, actually is not without certain advantages.<BR>
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Regards<BR>
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Arthur<BR>
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*challenging samples supplied under CDAs by clients can be the basis for extending one's capabilities and methodologies. OK - you cannot publish what you have done with a client's sample. But a new approach which worked well CAN be applied to systems which you are working on in a 'pure research' context. And then of course published. Been there - done that. A.<BR>
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<BLOCKQUOTE>Just though I would add a little to this thread:<BR>
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<FONT COLOR="#0000FF">(4) I agree with Arthur that to date most biotech companies have not been terribly interested in reversible association thermodynamics. This is probably going to change at least somewhat due to (3) above. <BR>
</FONT>I have worked with a number of companies on drugs that interact with tubulin and in each case I was allowed to pursue the full thermodynamic analysis of the AUC data. It has a lot to do with how you sell it to them, who their research director is, and how successful you are at convincing readers, reviewers and the company the data has predictive value. Good data and rigorous analysis is never a bad idea, even if companies are focused on their bottom line.<BR>
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Dr. John J. "Jack" Correia<BR>
Department of Biochemistry<BR>
University of Mississippi Medical Center<BR>
2500 North State Street<BR>
Jackson, MS 39216<BR>
(601) 984-1522 <BR>
fax (601) 984-1501 <BR>
email address: jcorreia@biochem.umsmed.edu <BR>
homepage location: http://biochemistry.umc.edu/correia.html<BR>
dept homepage location: http://biochemistry.umc.edu/<BR>
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