[RASMB] Segal paper mail 1

[Ariel Lustig]

Dear colleauges,

Long time you heard at conferences and via rasmb communication about the SEGAL  computer- program for sedimentation equilibrium SE evaluation. Some of you even try to use it. 

The idea behind the program was to create >> a program  for  the  poor <<, We mean  for  

non-specialists, who just  want  to  achieve  the  molecular masses  of the  sample they deal with, not to worry for  equilibrated  or dialysed  buffer/ blank ( not always possible) or even  for  conservation of mass during a run , that is often not self evident for  biological  solutions.

Until now  every one could get  the  information  from the  net, (see  reference 12  of the attached  Segal-paper.) but  this  net information was uncompleted without the theory section.

WE attached   a second   NANOMEDICINE paper,(on a following  mail to you to prevent  to overload  this  mail) as an example,there are electron  micrographs of samples that  were also run by SE and evaluated  with  Segal.  This non homogene particles with dark  background  that represent  low molecular  weight  particles and  causes  a huge  base absorption in the Auc cell. Even so, the  information  about the  nano- particles  is  clear.

A third  FASEB paper ( attached separatly on a third mail), shows  how  the  achieved  Segal  evaluated  results  open new  horizons for  coil-coil binding.  Te past year  I presented at  the London meeting the Nature Structure LiF /Lipase  paper calculated with Segal.

Gia and  me hope to help with this program to solve also some scientific non-solved questions  with this simple instrument  compared to new soffisticated  programs.

Gia Machaidse  gia machaidse at unibas.ch

Ariel Lustig       ariel.lustig at bluewin.ch
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