[RASMB] Substrate & quaternary structure

[JA KORNBLATT]

dear holger
plasminogen undergoes a large structural change when it binds the ligand,
6-aminohexanoate. the latter is a lysine analogue. the stoke's radius
increases by about 20% on binding. auc has been a favourite tool of people
working on this protein for the last 35 years.
there are several good reviews of the plasminogen literature. if you are
interested, you can easily retrieve  my 2000 review in bba 1481: 1-10.
it'a as good a place to start as any. the names to note in the field are
ponting, marshall, christensen, mangel, tranqui, markus, brockway,
castellino and many others.
best regards
jack kornblatt


On Wed, 23 Feb 2005, Holger Strauss wrote:

> Date: Wed, 23 Feb 2005 18:28:24 +0100 (MET)
> From: Holger Strauss <strauss at fmp-berlin.de>
> To: rasmb at server1.bbri.org
> Subject: [RASMB] Substrate & quaternary structure
>
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> Hi RASMBers,
>
> I'm looking for some inpsiring reading about a situation where binding of
> small ligands/substrates/cofactors/prosthetic groups influences/regulates
> the quaternary structure and function of the protein/enzyme; ideally,
> where structural models for such phenomena are developed (better still,
> where such phenomena have been investigated with AUC).
>
> Thanks a lot in advance!
>
> Cheers, Holger
>
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> Holger Strauss
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