[RASMB] Substrate & quaternary structure

[pjgb at mrc-lmb.cam.ac.uk]

Dear Holger,

What about the considerable canon of work by Howard Schachman on Aspartate 
Transcarbamalase?  This enzyme is allosteric, with separate catalytic and 
regulatory subunits, a (C3)2 (R2)3 structure, both activators and 
repressors, and much of Howard's work was historic with the AUC.

Jo Butler

--On Wednesday, February 23, 2005 6:28 pm +0100 Holger Strauss 
<strauss at fmp-berlin.de> wrote:

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> Hi RASMBers,
>
> I'm looking for some inpsiring reading about a situation where binding of
> small ligands/substrates/cofactors/prosthetic groups influences/regulates
> the quaternary structure and function of the protein/enzyme; ideally,
> where structural models for such phenomena are developed (better still,
> where such phenomena have been investigated with AUC).
>
> Thanks a lot in advance!
>
> Cheers, Holger
>
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P.J.G. Butler,
MRC Laboratory of Molecular Biology,
Hills Road, Cambridge, CB2 2QH, UK.
Tel. +44 (0)1223 402296