[RASMB] Amyloid fibrils and Fujita approach

[Ewa Folta-Stogniew]

Sabine,

I had analyzed abeta-peptide assembly distributions by 
SEC-MALLS.  Since MW determination from LS is independent of shape, 
SEC-MALLS is thus well suited for this heterogeneous system.

Ewa



At 02:34 PM 4/4/2013, Sabine Kaltofen wrote:
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>Dear all,
>
>has anyone of you tried to describe the size/molecular weight of 
>amyloid fibrils using the Fujita approach?
>I am after a rather accurate determination of the MW (distribution) 
>of fibrils.
>Therefore, using a scaling law to relate s with M seems the most 
>rigorous thing to do. I am, however not aware of any literature 
>where this approach has been used for peptide/protein fibrils.
>Am I missing a major point here, why this is not applicable?
>
>All comments, experiences and thoughts are greatly appreciated!
>
>Best wishes
>
>Sabine
>
>
>
>Mind your carbon footprint: please don't print this message.
>
>
>Sabine Kaltofen
>Biochemistry & Structural Biology
>Lund University
>sabine.kaltofen at biochemistry.lu.se
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