[RASMB] ACA Training Workshop WK.01 - Biological Small Angle Solution Scattering Theory and Practice

[Kushol Gupta]

ACA Training Workshop WK.01

Biological Small Angle Solution Scattering Theory and Practice

2013 ACA meeting in Hawaii

 

Reserve your space now! The early registration discount ends May 31*.

 

Small angle solution scattering (SAS) has recently experienced a dramatic
increase in popularity within the structural biology community.

As molecular biological systems of interest become ever increasingly
complex, SAS is providing valuable insight into structure and conformational
behavior in solution. The availability of synchrotron radiation and neutron
sources, commercial lab-source SAXS instrumentation, low-noise detectors,
powerful computing hardware, and better algorithms has made the technique
accessible to a much larger audience than ever before.

 

This dual-track workshop brings together leading beamline scientists as well
as experts in laboratory-based BioSAXS sources to provide a unique,
practical "HOW TO" course in SAS data collection, processing, and
interpretation.

 

Track A:     Getting Started in Biological Small Angle Solution Scattering:
your practical HOW TO guide.

            Topics: Basics of scattering, Guinier analysis, monodispersity &
aggregation, Kratky plots,

            folding & flexibility, molecular mass determination, P(r)
function, sample preparation and 

            characterization tips, shape reconstruction, using lab sources,
neutron scattering basics, 

            publishing your first data: what you should know.

 

            Speakers: Angela Chriswell (Rigaku), Javier Perez (Soleil),
Srinivas Chakravarthy (APS), 

                      Jill Trewhella (U. Sydney), Richard Gillilan
(MacCHESS, Cornell U.), Andreas Keilbach (Anton Paar), 

                      Juergen Graf (Incoatec), (Bruker speaker, to be
confirmed)

 

Track B:     Using Advanced Methods in Biological Small Angle Solution
Scattering

            Topics: evaluating SAXS data, molecular mass, flexibility,
modeling software: FOXS, MES, 

            FoxDOCK, AllosMod-FOXS, strategy, inference-free data,
similarity maps, contrast matched 

            heavy atom labeling, ensemble analysis, NMR+SAXS, ab initio
modeling at the residue level,

            building a lab source for BioSAXS.

 

            Speakers:  Robert Rambo, Michal Hammel, Greg Hura (ALS), Kushol
Gupta (Perelman School of Medicine, U. Penn)

                                Andreas Keilbach (Anton Paar),  Juergen Graf
(Incoatec), (Bruker speaker, to be confirmed), 

                                Angela Chriswell (Rigaku), and others to be
confirmed.

 

Workshop format: serious attention will be given to hands-on practical
exercises.

 

After the Workshop:

 

Several highly relevant BioSAXS-related sessions are scheduled for the
beginning of the regular ACA meeting to immediately follow this workshop:
TR.01 (Probing Biological Structure With HT SAS), 09.01 Dynamic & Flexible
Structures in Biomolecules,

09.03 Membrane Protein Scattering. Students of this workshop will be in an
excellent position to take full advantage these cutting-edge presentations
and are thus encouraged to attend and exchange ideas with the many SAS
experts in attendance.

 

For more information:  <http://www.amercrystalassn.org/wk.01>
www.amercrystalassn.org/wk.01

 

*To Register:  <http://www.amercrystalassn.org/2013-registration>
www.amercrystalassn.org/2013-registration

 

Note: students only attending the training Workshop do not need to pay the
full ACA registration fee. 

To register for just the workshop, fill out and return the ACA registration
form (PDF file), paying the workshop fee only.

 

 

Kushol Gupta, Ph.D.

Research Associate - Van Duyne Laboratory 

Perelman School of Medicine

University of Pennsylvania 

 <BLOCKED::mailto:kgupta at stwing.upenn.edu> kgupta at mail.med.upenn.edu

215-573-7260 / 267-259-0082

 

 

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