[RASMB] Amyloid fibrils and Fujita approach

Ewa Folta-Stogniew ef55 at email.med.yale.edu
Fri Apr 5 10:35:59 PDT 2013


Sabine,

I had analyzed abeta-peptide assembly distributions by 
SEC-MALLS.  Since MW determination from LS is independent of shape, 
SEC-MALLS is thus well suited for this heterogeneous system.

Ewa



At 02:34 PM 4/4/2013, Sabine Kaltofen wrote:
>Content-type: multipart/alternative;
>  boundary="Boundary_(ID_PrmXHidevivbwl7flx4wTQ)"
>Content-language: en-GB
>
>
>
>Dear all,
>
>has anyone of you tried to describe the size/molecular weight of 
>amyloid fibrils using the Fujita approach?
>I am after a rather accurate determination of the MW (distribution) 
>of fibrils.
>Therefore, using a scaling law to relate s with M seems the most 
>rigorous thing to do. I am, however not aware of any literature 
>where this approach has been used for peptide/protein fibrils.
>Am I missing a major point here, why this is not applicable?
>
>All comments, experiences and thoughts are greatly appreciated!
>
>Best wishes
>
>Sabine
>
>
>
>Mind your carbon footprint: please don't print this message.
>
>
>Sabine Kaltofen
>Biochemistry & Structural Biology
>Lund University
>sabine.kaltofen at biochemistry.lu.se
>_______________________________________________
>RASMB mailing list
>RASMB at list.rasmb.org
>http://list.rasmb.org/listinfo.cgi/rasmb-rasmb.org




More information about the RASMB mailing list