[RASMB] Amyloid fibrils and Fujita approach

[Sabine Kaltofen]

Dear all,

has anyone of you tried to describe the size/molecular weight of amyloid fibrils using the Fujita approach?
I am after a rather accurate determination of the MW (distribution) of fibrils.
Therefore, using a scaling law to relate s with M seems the most rigorous thing to do. I am, however not aware of any literature where this approach has been used for peptide/protein fibrils.
Am I missing a major point here, why this is not applicable?

All comments, experiences and thoughts are greatly appreciated!

Best wishes

Sabine



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Sabine Kaltofen
Biochemistry & Structural Biology
Lund University
sabine.kaltofen at biochemistry.lu.se
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