[RASMB] Protein Therapeutic Lower Stability Limit

Doyle, Michael michael.doyle at bms.com
Thu Jan 27 10:00:10 PST 2011


All:

Does anyone know if there is public information (literature) about protein therapeutic drugs in the clinic or market that have unusually low thermal denaturation Tm values?  Tm values are of course very dependent on solution conditions, and it is not clear to me how Tm values measured in vitro compare to the Tm the protein would have in the crowded in vivo setting.  Regardless, for benchmark purposes, what are the lowest Tm values of clinical/marketed protein therapeutics as measured by DSC or other in vitro thermal methods under say, neutral pH and physiologic-like salt conditions?

Mike

________________________________
This message (including any attachments) may contain confidential, proprietary, privileged and/or private information. The information is intended to be for the use of the individual or entity designated above. If you are not the intended recipient of this message, please notify the sender immediately, and delete the message and any attachments. Any disclosure, reproduction, distribution or other use of this message or any attachments by an individual or entity other than the intended recipient is prohibited.
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://list.rasmb.org/pipermail/rasmb-rasmb.org/attachments/20110127/3bbb1f53/attachment.htm>


More information about the RASMB mailing list