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<p class="MsoNormal">All:<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Does anyone know if there is public information (literature) about protein therapeutic drugs in the clinic or market that have unusually low thermal denaturation Tm values? Tm values are of course very dependent on solution conditions,
and it is not clear to me how Tm values measured in vitro compare to the Tm the protein would have in the crowded in vivo setting. Regardless, for benchmark purposes, what are the lowest Tm values of clinical/marketed protein therapeutics as measured by DSC
or other in vitro thermal methods under say, neutral pH and physiologic-like salt conditions?<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Mike<o:p></o:p></p>
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