[RASMB] Biophysical Positions (BS/MS and PhD)

[Michael L Doyle]

Dear RASMBers:

Two new biophysical characterization positions are open in our 
department to support discovery of protein therapeutics.  One is at the 
Associate Research Scientist level (BS or MS degree required) and also 
requires experience in protein purification.  The other position is at 
the Research Investigator level (PhD and preferably 2-3 years of 
post-doctoral training required).  Details are below.  If interested, 
please apply to the Bristol-Myers Squibb web site as described below, 
and also send information direct to me. Please feel welcome to call or 
email if you have any questions.

Sincerely,
Mike Doyle, PhD
Group Leader, Protein Biochemistry
(609) 252-3175

_Job Description - Associate Research Scientist_
Express recombinant proteins in E. coli or yeast. Purify recombinant 
proteins from E. coli, baculovirus infected insect cells, and other 
sources. Ability to work independently and develop multi step 
chromatography protein purification protocols from experience or from 
researching the existing scientific literature. Biophysical 
characterization of protein protein interactions using kinetic or 
equilibrium methods. Characterize the protein structure, stability and 
aggregation state of protein therapeutic agents and protein targets. 
Closely collaborate with scientists within own department and with 
external customers.
_Position Requirements_
B.S. or M.S. in Biochemistry or related field. Two or more years of post 
degree experience would be preferred. Experience with  recombinant DNA 
vectors and optimizing culture conditions to express milligram to gram 
quantities of proteins in E. coli or yeast. Experience using multi-step 
chromatography methods.  Experience with analytical ultracentrifugation, 
surface plasmon resonance, microcalorimetry, or light scattering would 
be an advantage.

_Job Description - Research Investigator_
Study protein-protein and protein-small molecule interactions to support 
drug discovery. Use Analytical Ultracentrifugation, Surface Plasmon 
Resonance, Calorimetry, Light Scattering and other biophysical assays to 
select protein therapeutic agents and characterize protein targets. 
Characterize of protein structure, stability and aggregation state. 
Conduct quantitative analysis of protein interactions.  Collaborate in 
multidisciplinary drug discovery teams. Very strong communication skills 
are required, both written and verbal.
_Position Requirements_
PhD in Biochemistry or related field, and 2-3 years of postdoctoral 
experience is preferred.  The ideal candidate will have demonstrated 
excellent scientific leadership abilities as evidenced by publications 
and presentations at scientific meetings.  Biophysical characterization 
of protein-protein interactions using kinetic or equilibrium methods. 
Experience with analytical ultracentrifugation, surface plasmon 
resonance, or microcalorimetry would be an advantage. Protein 
purification experience would be an advantage. Effective verbal and 
written communication skills.

Applications must be made at  www.bms.com (click on "Job Search" in the 
"Quick Links" section in middle of web page, and register).  To apply, 
register as a guest, locate the position by doing a "detailed search" 
with the requisition number 19902 (Associate Scientist, BS/MS) or 19867 
(Research Investigator, PhD w/post-doc) .  (Please also send your CV to 
michael.doyle at bms.com).

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