[RASMB] averages from SV
Peter Schuck
pschuck at helix.nih.gov
Mon Jan 30 16:35:24 PST 2006
Although I consider myself passionate at times about science, it wasn't
my intention to trash anyone. As this is an open forum for discussion,
my intentions are to address scientific problems with honesty,
transparency, and the best possible solution. I certainly also didn't
want to sell anything (my programs are free for all, and you won't find
any report of sn or sz averages in them). As I tried to explain, the
problems with these averages occur with every method where a single
species produces a smooth function, and they strongly diminish anytime
you get baseline-separated peaks.
One last comment - there are certainly many publications (including some
of my own) using *weight* averages, which I tried to make abundantly
clear are thermodynamically completely rigorous and can be analyzed
perfectly well for interacting or non-interacting systems. However, I'm
not aware of a single one using number-averages, z-averages, or z+1
averages derived from integration of sedimentation coefficient
distributions for quantitative analysis (the closest to this is perhaps
a manuscript in preparation I seem to remember being cited by Jack
Correia in his review).
Peter
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