AW: [RASMB] frictional ratio

[Claus Urbanke]

Holger,

there has been a survey by V.N. Uversky (Eur. J. Biochem., 269, 2-12 (2002)
where Stoke's radii data on many proteins and their different denatured
states are collected. He gives empirical formulae for a linear relationship
between log(R(Stokes)) and log(M). You can calculate f/f(0) from those. The
ratio is size dependent and 2.3 comes out for a GuaHCl dentaured protein
with a molar mass of 21 kg.

Hope this helps
Best wishes

Claus





Claus Urbanke
Medical School Hannover
Biophysical Chemistry OE 8830
D-30625 Hannover
Germany


-----Ursprüngliche Nachricht-----
Von: rasmb-bounces at rasmb.bbri.org [mailto:rasmb-bounces at rasmb.bbri.org] Im
Auftrag von Holger Strauss
Gesendet: Freitag, 9. Dezember 2005 22:46
An: rasmb at rasmb.bbri.org
Betreff: [RASMB] frictional ratio

Hi everybody,

I remember that the frictional ratio for a fully unfolded polypeptide
chain is around 2.3; but I can't remember the actual reference. Any hints?

A happy, peaceful and healthy 2006 to all!

Holger

_______________________________________________
RASMB mailing list
RASMB at rasmb.bbri.org
http://rasmb.bbri.org/mailman/listinfo/rasmb