[RASMB] Postdoctoral Position

[Michael G. Fried]

Dear Colleagues,

A postdoctoral position is available to study the DNA- and 
protein-interactions of the human O6-alkylguanine-DNA 
alkyltransferase protein.  This protein plays an important role in 
the repair of alkylated DNA and is also a target of chemotherapeutic 
agents.  The current project includes preparation of recombinant 
proteins, characterization of their binding to target and 
non-specific DNAs and analysis of their protein-protein interactions, 
using biochemical and biophysical techniques.   Some examples of our 
work in this area are:

DNA Binding Mechanisms of O6-Alkylguanine-DNA Alkyltransferase: 
Stoichiometry and Effects of DNA Base Composition and Secondary 
Structures on Complex Stability. M.G. Fried, S. Kanugula, J.L. 
Bromberg and A.E. Pegg, Biochemistry 35, 15295-15301 (1996).

Effects of Zinc Occupancy on Human O6 -Alkylguanine-DNA 
Alkyltransferase  J.J. Rasimas, S. Kanugula, P.M. Dalessio, I.J. 
Ropson, M.G. Fried and A.E. Pegg. Biochemistry 42, 980-990 (2003).

Interaction of O6-Alkylguanine DNA Alkyltransferase with DNA: Effects 
of Protein- and DNA-Alkylation.  J. J. Rasimas, A. E. Pegg and M.G. 
Fried. J. Biol. Chem. 278, 7973-7980 (2003).

Active-Site Alkylation Destabilizes Human O6-Alkylguanine DNA 
Alkyltransferase. J.J. Rasimas, P. Dalessio, I. Ropson, A.E. Pegg and 
M.G. Fried. Protein Science, 13, 301-305 (2004).

Individuals who wish to apply for this position should send a letter 
stating their interests and qualifications, a curriculum vitae, and 
the names and addresses (email, postal and telephone number) of three 
references to me at the address given below.

Thanks very much!
Sincerely,

Mike Fried
-- 
Michael G. Fried, Ph.D.
Professor                                                             
Department of Biochemistry and Molecular Biology, H171       
The Pennsylvania State University College of Medicine          
500 University Drive
Hershey, PA 17033

email: mfried at psu.edu
Telephone: (717) 531-5250
FAX: (717) 531-7072

http://fred.hmc.psu.edu/ds/retrieve/fred/investigator/mfried

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