[RASMB] hydrostatic pressures

[JA KORNBLATT]

the two kornblatts have worked with hydrostatic pressure as a perturbant
for a long time and with the auc for only a couple of years.

many of the changes induced by hydrostatic  pressures in the range of 1
bar to  4000 bar would be "easily" detected by auc analysis. this includes
shape changes such as the open/closed transition of plasminogen,
association/dissociation reactions, and native/denatured reactions.

the question: has anyone spent any idle moments reflecting on the question
of how much effort might be expended on building an auc cell that would
withstand a couple of thousand atmospheres pressure?
am i wasting the few remaining neurons thinking about the prospects or
would it be worth while giving it some effort?
any help you can give would be appreciated.
best regards
jack (kornblatt)