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<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black">Greetings, RASMBers,<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black">I'm happy to announce the immediate availability of SViMULATE version 1.1.0, my new sedimentation-velocity simulation program (sorry Apple and LINUX users-- it is only
compiled for computers running Windows 10 and higher with 64-bit architectures). You can download it here:
<a href="https://www.utsouthwestern.edu/research/core-facilities/mbr/software/" id="LPNoLPOWALinkPreview">
https://www.utsouthwestern.edu/research/core-facilities/mbr/software/</a> (scroll to the bottom of that page). The paper describing was recently published in European Biophysics Journal:
<a href="https://pubmed.ncbi.nlm.nih.gov/36890221/" id="LPNoLPOWALinkPreview_1">https://pubmed.ncbi.nlm.nih.gov/36890221/</a><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black">But why, you ask, would you want to download and use it? Here are some nifty features:<o:p></o:p></span></p>
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<span style="font-size:12.0pt">Allows an unlimited number of species.<o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1;background:white">
<span style="font-size:12.0pt">Has on-the-fly hydrodynamics calculations, so, for example, if you know M and frictional ratio, it automatically calculates s and D for you (several other such calculations are enabled).<o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1;background:white">
<span style="font-size:12.0pt">Offers a seamless interface with HullRad, the most excellent hydrodynamics calculation program by Karen Fleming & Patrick Fleming.<o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1;background:white">
<span style="font-size:12.0pt">You don't have to simulate a fixed number of scans or a fixed elapsed time; you can let the program make the endpoint decision for you.<o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1;background:white">
<span style="font-size:12.0pt">Allows addition of TI & RI Noise, in addition to stochastic noise from a normal distribution or an exponentially modified Gaussian distribution.<o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1;background:white">
<span style="font-size:12.0pt">Allows the input of a c(s) distribution, picking peaks therein to use as species in a subsequent simulation.<o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1;background:white">
<span style="font-size:12.0pt">Enables quick, interactive adjustments to be made to the simulation, and saves scan files only when you've adjusted the parameters to your liking.<o:p></o:p></span></li></ol>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black">For now, SViMULATE simulates data only for non-interacting, ideal species, but I'll probably add some non-ideality and simple interaction models in my abundant free time.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black">If you got your hands on a 1.0.x version, you might want to upgrade, as this most recent version includes a few bugfixes, a full manual, and the correction of at least
one very embarrassing typo.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black">So, take it for a spin! if you have any suggestions for improvement, just email me. I hope you have as much fun using it as I had programming it!<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white"><span style="font-size:12.0pt;color:black">Cheers,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black">Chad</span><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal" style="border:none;padding:0in"><o:p> </o:p></p>
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<p class="MsoNormal">Chad A. Brautigam, Ph.D.<o:p></o:p></p>
<p class="MsoNormal">Professor<o:p></o:p></p>
<p class="MsoNormal">Director, Macromolecular Biophysics Resource<o:p></o:p></p>
<p class="MsoNormal">Departments of Biophysics and Microbiology<o:p></o:p></p>
<p class="MsoNormal">UT Southwestern Medical Center<o:p></o:p></p>
<p class="MsoNormal">5323 Harry Hines Blvd.<o:p></o:p></p>
<p class="MsoNormal">Dallas, TX 75390-8816<o:p></o:p></p>
<p class="MsoNormal">Rm. ND10.214B<o:p></o:p></p>
<p class="MsoNormal">Phone: 214-645-6384<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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<p style="text-align:right"><span style="font-size:10pt;font-family:"Helvetica","sans-serif"; color:#666D70;">The future of medicine, today.</span></p>
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