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<p class="MsoNormal">Fellow RASMBers,<o:p></o:p></p>
<p class="MsoNormal">If you have ever struggled with alignment problems when using SV-AUC to quantify levels of soluble aggregates, then you might find this interesting:<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b>An optical alignment system improves precision of soluble aggregate quantitation by sedimentation velocity analytical ultracentrifugation<o:p></o:p></b></p>
<p class="MsoNormal">ABSTRACT:<o:p></o:p></p>
<p class="MsoNormal">Appropriate characterization of soluble aggregates is an important aspect of biologics development and manufacturing, and sedimentation velocity analytical ultracentrifugation (SV-AUC) is often used an orthogonal technique to size-exclusion
chromatography (SEC) for this purpose. Precise quantification of low levels of soluble aggregates by SV-AUC can be adversely impacted by improper cell alignment. This report describes the development of an optical system capable of quantifying cell alignment
that affords a substantial improvement compared to historical approaches.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">The journal provides temporary free access to the article:<o:p></o:p></p>
<p class="MsoPlainText"><a href="https://authors.elsevier.com/a/1V5iolbALfkA">https://authors.elsevier.com/a/1V5iolbALfkA</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">We look forward to future developments in the field. Thanks.<o:p></o:p></p>
<p class="MsoNormal">-Will<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" style="text-autospace:none"><b><span style="font-family:"Arial",sans-serif;color:#867870">William F. Weiss IV, Ph.D.<o:p></o:p></span></b></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#82786F">Principal Research Scientist<o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#82786F">Biophysical Characterization Group Leader<o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#82786F">Biopharmaceutical Research and Development</span><span style="font-size:10.0pt;font-family:ArialMT;color:#867870"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#D52B1E">Eli Lilly and Company<o:p></o:p></span></b></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#82786F">317.433.8260 (office) | 317.209.4748 (mobile)<o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#82786F"><a href="mailto:weisswf@lilly.com"><span style="color:blue">weisswf@lilly.com</span></a> |
<a href="http://www.lilly.com"><span style="color:blue">www.lilly.com</span></a><o:p></o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:10.0pt;font-family:ArialMT;color:#82786F"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-autospace:none"><span style="font-size:8.0pt;font-family:"Arial",sans-serif;color:#82786F">CONFIDENTIALITY NOTICE: This email message (including all attachments) is for the sole use of the intended recipient(s) and may contain
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