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<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=ES-TRAD
style='font-size:12.0pt'>Dear colleagues:<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=ES-TRAD
style='font-size:12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt'>We are glad to announce the availability of new
versions of our computer programs MONTEHYDRO and BROWFLEX for the simulation of
conformation and solution properties of models for flexible macromolecules and
nanoparticles in dilute solution. They are parts of the SIMUFLEX package, that
can be downloaded from our web site:<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt'><a
href="http://leonardo.inf.um.es/macromol/programs/programs.htm">http://leonardo.inf.um.es/macromol/programs/programs.htm</a><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt'>The new features are described in the User Guide of
each program. Among them, there is the noteworthy possibility of simulating
particles composed by quasi-rigid cores with connecting or hanging flexible
linkers or tails. This feature has enabled the simulation of partially, intrinsically
disordered (ID) proteins; this work is the subject of an article that I would
like, also, to bring to your attention:<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'>D. Amoros,
A.Ortega, J. Garcia de la Torre </span></font><span lang=EN-GB>“Prediction
of hydrodynamic and other solution properties of partially disordered proteins
with a simple, coarse-grained model” </span><i><span lang=FR
style='font-style:italic'>Journal of Chemical Theory and Computation</span></i><span
lang=FR>, 9, 1678-1685 (2013).<o:p></o:p></span></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'>For a complete
list of our recent publications, you may consult<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'><a
href="http://leonardo.inf.um.es/macromol/publications/lista-inver-noPDF.htm">http://leonardo.inf.um.es/macromol/publications/lista-inver-noPDF.htm</a><o:p></o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'>We hope that this
methodological contribution will contribute to extend the use of
dilute-solution properties for the strucutural elucidation of complex
biomacromolecules and nanoparticles.<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'>With my warmest
regards,<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'>Jose Garcia de la
Torre<o:p></o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-align:justify'><font size=3
face="Times New Roman"><span lang=FR style='font-size:12.0pt'><o:p> </o:p></span></font></p>
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