<html><head></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><font class="Apple-style-span" color="#950f0b">Dear John</font><div><font class="Apple-style-span" color="#950f0b"><br></font></div><div><font class="Apple-style-span" color="#950f0b">I guess that the most widely used software for this purpose is SEDNTERP. It is now cross-platform, and there is a web version:</font></div><div><font class="Apple-style-span" color="#950f0b"><br></font></div><div><font class="Apple-style-span" color="#950f0b"><a href="http://www.spinanalytical.com/auc-software.php">http://www.spinanalytical.com/auc-software.php</a></font></div><div><font class="Apple-style-span" color="#950f0b"><br></font></div><div><font class="Apple-style-span" color="#950f0b">Only snag is that the current versions call for rather unusual data file formats</font></div><div><font class="Apple-style-span" color="#950f0b"><br></font></div><div><font class="Apple-style-span" color="#950f0b">KInd regards</font></div><div><font class="Apple-style-span" color="#950f0b"><br></font></div><div><font class="Apple-style-span" color="#950f0b">Arthur</font></div><div><font class="Apple-style-span" color="#950f0b"><br></font></div><div><font class="Apple-style-span" color="#950f0b">Professor Arthur J Rowe<br>NCMH/Food Sciences<br>University of Nottingham<br>Sutton Bonington<br>Leics LE12 5RD UK<br><br>Tel: +44 115 9516156<br><a href="mailto:arthur.rowe@nottingham.ac.uk">arthur.rowe@nottingham.ac.uk</a></font></div><div><font class="Apple-style-span" color="#950f0b"><br></font></div><div><br><div><div>On 17 Oct 2012, at 22:21, <a href="mailto:john_doran@vrtx.com">john_doran@vrtx.com</a> wrote:</div><br class="Apple-interchange-newline"><blockquote type="cite"><font size="2" face="sans-serif">Greetings fellow Rasmb members</font><br><br><font size="2" face="sans-serif">The issue has arisen on more than one
occasion for us to look at the association state of small molecules ( i.e
molecules under 1000 MW) using the AUC. When there is plenty of material
it is easy enough to directly measure Vbar using densitometry, but of course
there are also occasions where the material is precious and there is not
nearly enough for densitometry. Does anyone know of any alternative physical
methods or getting Vbar values generated from theory that may be used in
lieu of densitometry? </font><br><br><font size="2" face="sans-serif">Thank you in advance for any replies
that are sent to address this problem!</font><br><br><br><font size="2" face="sans-serif">John D Doran, Ph.D.<br>Protein Biochemistry<br>Vertex Pharmaceuticals Inc.<br>130 Waverly Street<br>Cambridge, MA 02139<br>617-444-6142</font><br>
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