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<DIV><FONT size=2 face=Arial><SPAN
class=794195221-19032012>RASMB,</SPAN></FONT></DIV>
<DIV><FONT size=2 face=Arial><SPAN
class=794195221-19032012></SPAN></FONT> </DIV>
<DIV><FONT size=2 face=Arial><SPAN class=794195221-19032012>I am releasing today
a completely-redone version of my program SVEDBERG for whole-boundary
analysis of single species, tightly-associated oligomers or complexes, and
mixtures. This version has a user-friendly interface similar to that of
DCDT+. Note that I am giving a workshop on this version at the AUC2012 meeting
in San Antonio next week.</SPAN></FONT></DIV>
<DIV><FONT size=2 face=Arial><SPAN
class=794195221-19032012></SPAN></FONT> </DIV>
<DIV><FONT size=2 face=Arial><SPAN class=794195221-19032012>The features of this
version are detailed at my software site, <A
href="http://www.jphilo.mailway.com/svedberg.htm">http://www.jphilo.mailway.com/svedberg.htm</A>,
so I will mention only a few of the new ones here:</SPAN></FONT></DIV>
<DIV><FONT size=2 face=Arial><SPAN
class=794195221-19032012></SPAN></FONT> </DIV><SPAN
class=794195221-19032012>
<LI><FONT size=2 face=Arial>Improved Lamm equation solution gives <I>s</I>,
<I>D</I>, and <I>M</I> values for each species with theoretical accuracy of
better than 0.1%, and will work for small peptides</FONT></LI>
<LI><FONT face=Arial><FONT size=2>Allows direct conversion of a <I>c(s)</I>
distribution from SEDFIT into an equivalent mixture model, allowing
determination of true confidence intervals for <SPAN
class=794195221-19032012>all </SPAN>the species fractions<SPAN
class=794195221-19032012> </SPAN>and sedimentation coefficients<SPAN
class=794195221-19032012> simultaneously</SPAN></FONT></FONT></LI>
<LI><FONT size=2 face=Arial>Allows use of <U>any</U> of the current methods for
handling systematic noise in the raw scans</FONT></LI>
<LI><FONT face=Arial><FONT size=2><SPAN class=794195221-19032012>(especially for
the biotech crowd) </SPAN>Generates a log file that records every step of the
data analysis, every option selected, every intermediate fitting result
(including a table and graph), when it was done, and by whom (for computers with
authenticated log-in servers)</FONT></FONT></LI>
<LI><FONT face=Arial><FONT size=2>Evaluates fitted parameter confidence
intervals using any of three orthogonal approaches: <I>F</I> statistics, the
bootstrap method, or the Monte Carlo method</FONT></FONT></LI>
<LI><FONT size=2 face=Arial>Generates nicely formatted printed reports with
tables, and which document every factor that influences the results. These
reports (with graphs) can be pasted into<SPAN
class=794195221-19032012> your word processor</SPAN> or electronic lab
notebook</FONT></LI>
<DIV></SPAN><SPAN class=794195221-19032012><FONT size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=794195221-19032012><FONT size=2 face=Arial>Best regards, and
looking forward to seeing many of you in San Antonio,</FONT></SPAN></DIV>
<DIV><SPAN class=794195221-19032012><FONT size=2
face=Arial></FONT></SPAN> </DIV>
<DIV><SPAN class=794195221-19032012><FONT size=2
face=Arial>John</FONT></DIV></SPAN></BODY></HTML>