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<div class="MsoNormal"><span style="font-size:12.0pt">A postdoctoral position is
available in the Late Stage Pharmaceutical and Process Development Department in
the lab of Steven J. Shire to investigate the rheological properties of
monoclonal antibodies. Previous work done in this research program has
established a link between protein self-association behavior and the viscosity
of the Mab formulation. In particular studies using three closely related MAbs
have focused on contributions due to sequence differences, which has resulted
in collaboration with Mab Engineering in Research. Several charge based mutants
have been generated and will be used to further explore the linkage between
charge distribution and viscoelastic behavior.<o:p></o:p></span></div>
<div class="MsoNormal"><span style="font-size:12.0pt"><b> <o:p></o:p></b></span></div>
<div class="MsoNormal"><span style="font-size:12.0pt"><b>Requirements:<o:p></o:p></b></span></div>
<div class="MsoNormal"><span style="font-size:12.0pt"> <o:p></o:p></span></div>
<div class="MsoNormal"><span style="font-size:12.0pt">A Ph.D. in biophysics,
biophysical chemistry or a related discipline.<span style="mso-spacerun:
yes"> </span>The candidate must have excellent biophysical and/or protein
biochemistry skills and hands-on experience or knowledge of the use of
different biophysical analytical technologies. The candidate must be highly
self-motivated, have excellent organization, communication, interpersonal and
collaborative skills, and be willing to work independently.<span style="mso-spacerun: yes"> </span><o:p></o:p></span></div>
<div class="MsoNormal"><span style="font-size:12.0pt"> <o:p></o:p></span></div>
<div class="MsoNormal"><span style="font-size:12.0pt"><b>To apply: </b></span><span style="font-size:12.0pt">Please contact and submit resume to Steve Shire at
<a href="mailto:shire.steve@gene.com">shire.steve@gene.com</a><o:p></o:p></span></div>
<div class="MsoNormal"><span style="font-size:12.0pt"> <o:p></o:p></span></div>
<div class="MsoNormal"><span style="font-size:12.0pt"> <o:p></o:p></span></div>
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<div apple-content-edited="true"> <div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: Helvetica; font-size: medium; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><span class="Apple-style-span" style="border-collapse: separate; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; -webkit-text-decorations-in-effect: none; text-indent: 0px; -webkit-text-size-adjust: auto; text-transform: none; orphans: 2; white-space: normal; widows: 2; word-spacing: 0px; "><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><span class="Apple-style-span" style="border-collapse: separate; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; -webkit-text-decorations-in-effect: none; text-indent: 0px; -webkit-text-size-adjust: auto; text-transform: none; orphans: 2; white-space: normal; widows: 2; word-spacing: 0px; "><span class="Apple-style-span" style="border-collapse: separate; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; -webkit-text-decorations-in-effect: none; text-indent: 0px; -webkit-text-size-adjust: auto; text-transform: none; orphans: 2; white-space: normal; widows: 2; word-spacing: 0px; "><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Geneva" size="3" style="font: normal normal normal 12px/normal Geneva; font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; ">Steven J. Shire, Ph.D.</span></span></span></font></p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Geneva" size="3" style="font: normal normal normal 12px/normal Geneva; font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; ">Staff Scientist and Group Leader</span></span></span></font></p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Geneva" size="3" style="font: normal normal normal 12px/normal Geneva; font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; ">Late Stage Pharmaceutical and Processing Development Dept.</span></span></span></font></p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Geneva" size="3" style="font: normal normal normal 12px/normal Geneva; font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; ">MS #56-1A</span></span></span></font></p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Geneva" size="3" style="font: normal normal normal 12px/normal Geneva; font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; ">Genentech, Inc.</span></span></span></font></p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Geneva" size="3" style="font: normal normal normal 12px/normal Geneva; font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; ">1 DNA Way</span></span></span></font></p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Geneva" size="3" style="font: normal normal normal 12px/normal Geneva; font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; ">S. San Francisco, CA 94080</span></span></span></font></p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><font face="Geneva" size="3" style="font: normal normal normal 12px/normal Geneva; font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; "><span class="Apple-style-span" style="font-family: Geneva; ">650-225-2077 (VOICE)</span></span></span></font></p><font class="Apple-style-span" face="Geneva"><span class="Apple-style-span" style="font-family: Geneva; "><a href="mailto:shire.steve@gene.com">shire.steve@gene.com</a></span></font><br class="Apple-interchange-newline"></span></span></div></span></div></span></div> </div><br></body></html>