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<div>Dear RASMB colleagues,</div>
<div>the methods of choice to characterize peptide oligomerization in solution so far in my view were AUC in equilibrium mode or static light scattering methods...</div>
<div>Recently, I heart about attempts to investigate peptide oligomerization as function of pH, buffer composition, etc. by electron spray mass spectroscopy. Are there opinions around about how MS methods in doing that compare to the more classical methods
as mentioned above. I can hardly believe how MS could work without significantly influencing weak interactions or change equilibria...</div>
<div>Thanks for any comment on that topic.</div>
<div>Best regards,</div>
<div>Hans-Joachim.</div>
<div>Ps: also grateful for any literature of review references on this topic...</div>
<div> </div>
<div><font face="Tahoma, sans-serif" size="1">============================================<font face="Arial, sans-serif" size="3">
<br>
</font>Dr. Hans-Joachim Schönfeld<font face="Arial, sans-serif" size="3"> <br>
</font>F. Hoffmann-La Roche Inc.<font face="Arial, sans-serif" size="3"> <br>
</font>Preclinical research, B93/5.44<font face="Arial, sans-serif" size="3"> <br>
</font>CH-4070 Basel<font face="Arial, sans-serif" size="3"> <br>
</font>Switzerland<font face="Arial, sans-serif" size="3"> </font></font></div>
<div><font face="Arial, sans-serif" size="3"> </font></div>
<div><font face="Tahoma, sans-serif" size="1">Tel. (+41) 61 688 28 95<font face="Arial, sans-serif" size="3">
<br>
</font>Fax. (+41) 61 688 90 60<font face="Arial, sans-serif" size="3"> <br>
</font><a href="mailto:hans-j.schoenfeld@roche.com"><font color="#0000FF"><u>mailto:hans-j.schoenfeld@roche.com</u></font></a><font face="Arial, sans-serif" size="3"> </font></font></div>
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