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<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Hello-<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Although
this mailing group has an AUC focus, perhaps some among you are
interested in expanding your arsenal of techniques… <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>We at Wyatt
Technology have developed an in vitro method, concentration gradient dynamic
light scattering, which enables quantitative characterization of macromolecular
interactions. Experiments can take several hours, and, depending on
the protein size, require only femtomoles of sample. <o:p></o:p></span></p>
<p class=MsoNormal style='margin-top:12.0pt'><span style='font-family:"Calibri","sans-serif"'>The
technique is detailed in our paper, “Free-solution, label-free protein
protein interactions characterized by dynamic light scattering.”
The paper was published in the January 20, 2010 issue of Biophysical
Journal (http://www.cell.com/biophysj/), and featured on the journal cover.
<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Although
dynamic light scattering has been used extensively to characterize
macromolecules since the 1970s, historically it has not been a practical
technique for quantification of macromolecular interactions. We believe
that the developments discussed in our paper, including the orthogonal use of
static light scattering, will have a profound impact, and that this impact will
extend beyond conventional light scattering users to all those interested in
accurate characterization of macromolecular interactions. <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Perhaps
this technique would be beneficial for you. Please feel free to contact
me if you have any questions.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Amy Hanlon<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>**************************************<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Amy Hanlon<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Research
and Development<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Wyatt
Technology Corporation<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>6300 Hollister
Avenue<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>Santa
Barbara, CA 93117<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>(805)
681-9009 x 269<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'>***************************************<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
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