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Dear all-<br>
I can only echo Steve's sadness on the passing of Michael Creeth. My
recollection of him is that he was always patient, kind and welcoming
to AUC newcomers. His research was top-notch, and his heritage in the
form of his graduate students, post docs and visiting scientists is
astonishing.<br>
Tom Laue<br>
<br>
Steve Harding wrote:
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<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif"; color: black;">Dear
All<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif"; color: black;"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif"; color: black;">It
is with great sadness I have to report the death on Friday of
one of the great pioneers of the analytical ultracentrifuge, Dr.
Michael Creeth.
<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif"; color: black;"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif"; color: black;">Mike
(born 1924) was a graduate of Nottingham</span><span
style="font-size: 10pt; font-family: "Arial","sans-serif"; color: black;">
a</span><span
style="font-size: 10pt; font-family: "Arial","sans-serif";">nd did his
PhD with D.
“Doj” Jordan on one of the earliest Model E’s. He then
moved to the vibrant Wisconsin in the early 50’s to do a postdoc with
Lou
Gosting and then took up a post at Adelaide – his 1<sup>st</sup> PhD
students were Don Winzor and Laurie Nichol. In 1960 he moved back to
England at
the Lister Institute - which was still running a Svedberg oil turbine
centrifuge - and then in 1978 to Bristol before he retired in 1984. It
was there I had the pleasure of working with him as a postDoc on what
had
become since the Lister his main field of interest, mucus
glycoproteins, where
his work is still widely known.<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";">Mike
was a true gentlemen and absolutely meticulous towards his science: a
highly
respected and distinguished practitioner. Besides his seminal work on
diffusion in the 50’s and 60’s emanating from his time with Gosting
and his work on analytical isopycnic density gradient sedimentation in
the 70’s
and 80’s his most notable contribution to science was probably in his
early days at Nottingham – with Jordan and Gullander he discovered the
hydrogen bonding between the base pairs of DNA (2 papers published in
1949 in
J. Chem. Soc., pages 1406-1409 and 1409-1413), 2 years before the
Chargraff
rules of base pairing was published. The existence of the H-bonds was
crucial
of course to the 1953 discovery of Watson and Crick.<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";">Last
September he was invited to talk at the Svedberg 125<sup>th</sup>
birthday
meeting at Uppsala – I was going to go with him but he couldn’t go
in the end due to failing health. He gave me the great honour of
presenting his
talk – if anyone wants to see a copy of this lecture it’s on:<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";"><a
moz-do-not-send="true"
href="http://www.nottingham.ac.uk/ncmh/lecture_notes/Svedberg_125th_anniversary_JMCreeth_talk_Sep09.pdf">http://www.nottingham.ac.uk/ncmh/lecture_notes/Svedberg_125th_anniversary_JMCreeth_talk_Sep09.pdf</a><o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";">Thankfully
he was able to complete his article for the special Svedberg
commemorative
edition of Macromolecular Bioscience.<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";">So
goodbye Mike, we will miss you – and we forgive you for making us wear
those
silk gloves before handling Model E rotors!<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size: 10pt; font-family: "Arial","sans-serif";">Steve
Harding<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family: "Arial","sans-serif";"> </span><span
style="font-size: 10pt; font-family: "Arial","sans-serif";"><o:p></o:p></span></p>
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