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<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:black'>Dear All<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:black'>It is with great sadness I have to report the death on Friday of
one of the great pioneers of the analytical ultracentrifuge, Dr. Michael Creeth.
<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif";
color:black'>Mike (born 1924) was a graduate of Nottingham</span><span
style='font-size:10.0pt;font-family:"Arial","sans-serif";color:black'> a</span><span
style='font-size:10.0pt;font-family:"Arial","sans-serif"'>nd did his PhD with D.
“Doj” Jordan on one of the earliest Model E’s. He then
moved to the vibrant Wisconsin in the early 50’s to do a postdoc with Lou
Gosting and then took up a post at Adelaide – his 1<sup>st</sup> PhD
students were Don Winzor and Laurie Nichol. In 1960 he moved back to England at
the Lister Institute - which was still running a Svedberg oil turbine
centrifuge - and then in 1978 to Bristol before he retired in 1984. It
was there I had the pleasure of working with him as a postDoc on what had
become since the Lister his main field of interest, mucus glycoproteins, where
his work is still widely known.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Mike
was a true gentlemen and absolutely meticulous towards his science: a highly
respected and distinguished practitioner. Besides his seminal work on
diffusion in the 50’s and 60’s emanating from his time with Gosting
and his work on analytical isopycnic density gradient sedimentation in the 70’s
and 80’s his most notable contribution to science was probably in his
early days at Nottingham – with Jordan and Gullander he discovered the
hydrogen bonding between the base pairs of DNA (2 papers published in 1949 in
J. Chem. Soc., pages 1406-1409 and 1409-1413), 2 years before the Chargraff
rules of base pairing was published. The existence of the H-bonds was crucial
of course to the 1953 discovery of Watson and Crick.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Last
September he was invited to talk at the Svedberg 125<sup>th</sup> birthday
meeting at Uppsala – I was going to go with him but he couldn’t go
in the end due to failing health. He gave me the great honour of presenting his
talk – if anyone wants to see a copy of this lecture it’s on:<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'><a
href="http://www.nottingham.ac.uk/ncmh/lecture_notes/Svedberg_125th_anniversary_JMCreeth_talk_Sep09.pdf">http://www.nottingham.ac.uk/ncmh/lecture_notes/Svedberg_125th_anniversary_JMCreeth_talk_Sep09.pdf</a><o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Thankfully
he was able to complete his article for the special Svedberg commemorative
edition of Macromolecular Bioscience.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>So
goodbye Mike, we will miss you – and we forgive you for making us wear those
silk gloves before handling Model E rotors!<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:"Arial","sans-serif"'>Steve
Harding<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:"Arial","sans-serif"'> </span><span
style='font-size:10.0pt;font-family:"Arial","sans-serif"'><o:p></o:p></span></p>
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