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<p class=MsoNormal>Dear Colleagues, <o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>Updated versions of SEDFIT (version 11.8) and SEDPHAT (version
6.5) have been released. They are available for download at<o:p></o:p></p>
<p class=MsoNormal> <o:p></o:p></p>
<p class=MsoNormal><a
href="https://sedfitsedphat.nibib.nih.gov/software/default.aspx">https://sedfitsedphat.nibib.nih.gov/software/default.aspx</a><o:p></o:p></p>
<p class=MsoNormal>or <o:p></o:p></p>
<p class=MsoNormal>(SEDFIT) <a
href="http://www.analyticalultracentrifugation.com/download.htm">http://www.analyticalultracentrifugation.com/download.htm</a><o:p></o:p></p>
<p class=MsoNormal>(SEDPHAT) <a
href="http://www.analyticalultracentrifugation.com/sedphat/download.htm">http://www.analyticalultracentrifugation.com/sedphat/download.htm</a><o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>There are new exciting features in SEDFIT:<o:p></o:p></p>
<p class=MsoNormal>-> computationally account for time-offsets and boundary
distortions from slow absorbance scanning of SV data<o:p></o:p></p>
<p class=MsoNormal>-> user-interface to HYDROPRO <o:p></o:p></p>
<p class=MsoNormal>-> rotor speed recommendation for SE experiments as
a calculator function (including minimal time to equilibrium)<o:p></o:p></p>
<p class=MsoNormal>-> general scaling law for c(s)<o:p></o:p></p>
<p class=MsoNormal>-> bimodal frictional ratio model [(f/f0)1 and (f/f0)2
for bimodal boundary data] combined with extra discrete species [for buffer offset
signals]<o:p></o:p></p>
<p class=MsoNormal>-> integration of particle size distributions from
DLS analysis<o:p></o:p></p>
<p class=MsoNormal>-> user-defined time-interval for fit updating<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>Important new features of SEDPHAT since the last release are:<o:p></o:p></p>
<p class=MsoNormal>-> partial-boundary modeling (i.e., constrain SV analysis
to non-overlapping radial regions of data points reporting about a certain s*-range)<o:p></o:p></p>
<p class=MsoNormal>-> three-site binding models<o:p></o:p></p>
<p class=MsoNormal>-> new data type for competition surface binding
data (SPR)<o:p></o:p></p>
<p class=MsoNormal>-> allow optional concentration correction factor
for isotherm analyses<o:p></o:p></p>
<p class=MsoNormal>-> computationally account for time-offsets and boundary
distortions from slow absorbance scanning of SV data<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>In addition, several minor bugs were fixed and functions for
increased user convenience were added in each program.<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>Please let me know if you encounter any problems or have any
suggestions.<o:p></o:p></p>
<p class=MsoNormal>Best regards,<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>Peter Schuck<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>Peter Schuck, PhD<o:p></o:p></p>
<p class=MsoNormal>Dynamics of Macromolecular Assembly<o:p></o:p></p>
<p class=MsoNormal>Laboratory of Bioengineering and Physical Science, NIBIB,
NIH<o:p></o:p></p>
<p class=MsoNormal>13 South Drive<o:p></o:p></p>
<p class=MsoNormal>Bldg 13, Rm 3N17<o:p></o:p></p>
<p class=MsoNormal>Bethesda, MD 20892<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>phone: (301) 435-1950<o:p></o:p></p>
<p class=MsoNormal>fax: (301) 480-1242<o:p></o:p></p>
<p class=MsoNormal>email: schuckp@mail.nih.gov<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
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