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<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'>Dear RASMB members,<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'>
I am currently hiring for a research associate in the Biochemical Pharmacology
group at Genentech in <st1:place w:st="on"><st1:City w:st="on">South San
Francisco</st1:City>, <st1:State w:st="on">California</st1:State></st1:place>.
We will be working with surface plasmon resonance assay (Biacore) to study
small-molecule/protein binding in the areas of fragment-based lead
identification, HTS hit validation, lead-optimization studies, and even some
late-stage compound work. The large dynamic range of the Biacore
(hundreds of picomolar to double-digit millimolar) means the technology and
group can contribute across the full range of the pharmaceutical discovery
process. The group is also very dynamic working on a large number of
projects so there will be opportunity to broaden skills in other areas of small
molecule discovery.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'>The job description and link to the site
to submit CVs is below. If you submit, please also let me know so I can
make sure it clears any hurdles at HR. Please also forward to individuals
you think may be interested, but not on this list. Thanks,<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Tony<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><a
href="http://jobpostings.gene.com/pljb/global_jsp/applicant/DisplayJob/JobDetails.jsp?display=1&pljbHome=/Genentech/external/applicant/index.jsp&id=18193">http://jobpostings.gene.com/pljb/global_jsp/applicant/DisplayJob/JobDetails.jsp?display=1&pljbHome=/Genentech/external/applicant/index.jsp&id=18193</a><o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><o:p> </o:p></span></font></p>
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<p class=MsoNormal style='line-height:11.25pt'><b><font size=1 color="#6e8210"
face=Verdana><span style='font-size:9.0pt;font-family:Verdana;color:#6E8210;
font-weight:bold'>Research Associate/Senior Research Associate<o:p></o:p></span></font></b></p>
</td>
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<p class=MsoNormal><font size=1 color=black face=Verdana><span
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<p class=MsoNormal><b><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black;font-weight:bold'>Job
ID<o:p></o:p></span></font></b></p>
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<td valign=top bgcolor=white style='background:white;padding:3.75pt 3.75pt 3.75pt 3.75pt'>
<p class=MsoNormal><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black'>1000023843<o:p></o:p></span></font></p>
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<p class=MsoNormal><b><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black;font-weight:bold'>Requisition
Number<o:p></o:p></span></font></b></p>
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<td valign=top bgcolor=white style='background:white;padding:3.75pt 3.75pt 3.75pt 3.75pt'>
<p class=MsoNormal><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black'>08-1000023843
RA/SRA BPH<o:p></o:p></span></font></p>
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<p class=MsoNormal><b><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black;font-weight:bold'>Location<o:p></o:p></span></font></b></p>
</td>
<td valign=top bgcolor=white style='background:white;padding:3.75pt 3.75pt 3.75pt 3.75pt'>
<p class=MsoNormal><st1:place w:st="on"><st1:City w:st="on"><font size=1
color=black face=Verdana><span style='font-size:8.5pt;font-family:Verdana;
color:black'>South San Francisco</span></font></st1:City><font size=1
color=black face=Verdana><span style='font-size:8.5pt;font-family:Verdana;
color:black'>, <st1:State w:st="on">CA</st1:State></span></font></st1:place><font
size=1 color=black face=Verdana><span style='font-size:8.5pt;font-family:
Verdana;color:black'><o:p></o:p></span></font></p>
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style='font-size:8.5pt;font-family:Verdana;color:black;font-weight:bold'>Job
Category<o:p></o:p></span></font></b></p>
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<p class=MsoNormal><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black'>Research -
Discovery<o:p></o:p></span></font></p>
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<p class=MsoNormal><b><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black;font-weight:bold'>Shift<o:p></o:p></span></font></b></p>
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<td valign=top bgcolor=white style='background:white;padding:3.75pt 3.75pt 3.75pt 3.75pt'>
<p class=MsoNormal><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black'>N/A<o:p></o:p></span></font></p>
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<p class=MsoNormal><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black'><o:p> </o:p></span></font></p>
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<p class=MsoNormal><b><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black;font-weight:bold'>Description<o:p></o:p></span></font></b></p>
</td>
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<tr>
<td bgcolor=white style='background:white;padding:3.75pt 3.75pt 3.75pt 3.75pt'>
<p class=MsoNormal><font size=1 color=black face=Verdana><span
style='font-size:8.5pt;font-family:Verdana;color:black'>Responsibilities:
<br>
We have an opening for a talented Research <br>
Associate or Sr. Research Associate to join our Biochemical Pharmacology
group in the Small Molecules Drug Discovery Division in <br>
<st1:place w:st="on"><st1:City w:st="on">South San Francisco</st1:City></st1:place>.
The successful candidate will be responsible for developing, optimizing,
validating and executing surface plasmon <br>
resonance (SPR as implemented with Biacore technology) assays that monitor
direct binding of small molecules to protein targets, in <br>
support of fragment screening efforts and advanced lead optimization
programs. The individual will work with an experienced Scientist to
conduct SPR experiments and analyze data across the lead discovery pipeline
including, but not limited to, fragment screening and HTS hit validation
for new projects, detailed binding characterization for lead-optimization
projects, and albumin binding for late-stage <br>
projects. The successful candidate will also help develop
innovative SPR methods and applications, and apply SPR and other
biophysical techniques within multi-disciplinary drug discovery project
teams. Close collaboration with the NMR scientists conducting complementary
fragment screens will be key to success, as will <br>
collaboration with our HTS group, medicinal chemists, structural
biologists, and pathway cell biology experts.<br>
<br>
Requirements: <br>
A B.S. in Biochemistry, Chemistry, Biophysics, or a related field is
required, with at least 3+ years industrial experience in using SPR /
Biacore technology to study protein-small <br>
molecule binding interactions. The candidate should have experience with
protein characterization and modification, as well as a solid understanding
of data analysis of SPR binding data. Experience with a variety of
different data handling and data management programs is desirable, as is
experience in integrating SPR data into drug discovery project teams.
Experience with other biophysical <br>
techniques such as calorimetry or thermal shift is a plus. Strong
teamwork, organizational skills, and written and oral communication <br>
skills are essential.<br>
<br>
DIVISION: Research<br>
REQUISITION NUMBER: 08-1000023843 RA/SRA BPH<o:p></o:p></span></font></p>
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