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<DIV>Just though I would add a little to this thread:</DIV>
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<DIV><FONT color=#0000ff>(4) I agree with Arthur that to date most biotech companies have not been terribly interested in reversible association thermodynamics. This is probably going to change at least somewhat due to (3) above. </FONT><BR></DIV>
<DIV>I have worked with a number of companies on drugs that interact with tubulin and in each case I was allowed to pursue the full thermodynamic analysis of the AUC data. It has a lot to do with how you sell it to them, who their research director is, and how successful you are at convincing readers, reviewers and the company the data has predictive value. Good data and rigorous analysis is never a bad idea, even if companies are focused on their bottom line.</DIV>
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<DIV> </DIV>-------------------------------------------------------------------<BR>Dr. John J. "Jack" Correia<BR>Department of Biochemistry<BR>University of Mississippi Medical Center<BR>2500 North State Street<BR>Jackson, MS 39216<BR>(601) 984-1522 <BR>fax (601) 984-1501 <BR>email address: jcorreia@biochem.umsmed.edu <BR>homepage location: <A href="http://biochemistry.umc.edu/correia.html">http://biochemistry.umc.edu/correia.html</A><BR>dept homepage location: <A href="http://biochemistry.umc.edu/">http://biochemistry.umc.edu/</A><BR>-------------------------------------------------------------------<BR><BR><BR><br clear=all> Individuals who have received this information in error or are not authorized to receive it must promptly return or dispose of the information and notify the sender. Those individuals are hereby notified that they are strictly prohibited from reviewing, forwarding, printing, copying, distributing or using this information in any way.
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