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<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'>Dear all, </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'>I have the possibility of a grant for a phD student
who would like to come in France and would be brilliant, since the selection is
mainly related to the excellence of the candidate.</span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'>The first dead lines are for a grant at CEA March 18<sup>th</sup>
and at ILL March 15<sup>th</sup>.</span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'>In case you knew an interested student, I would be
grateful if you could transmit him (or her) the attached proposal and suggest
him (her) to apply and contact me.</span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'>All the best</span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'>Christine</span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'> </span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt'>PhD subject.</span></font></p>
<p class=MsoNormal style='margin-right:0cm;margin-bottom:1.55pt;margin-left:
0cm'><font size=3 face="Times New Roman"><span lang=EN-GB style='font-size:
12.0pt'>Research field: </span></font><span lang=EN-GB>Life Sciences /
Molecular biophysics / Structural biology</span></p>
<p class=MsoNormal style='margin-right:0cm;margin-bottom:1.55pt;margin-left:
0cm'><font size=3 color=navy face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt;color:navy'> </span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt'>Titre : Interactions between solubilized membrane
transporters</span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt'>Only a limited number of high resolution 3D structures
of membrane proteins are available. Among other reasons, crystals of membrane
proteins are hard to obtain. For soluble proteins, favourable crystallisation
conditions are found when precipitant leads to weak inter-macromolecular
attractions. For membrane proteins, general rules may consider the presence of
detergent in the solution. We propose to study the relations between the
concentration of species in solutions (protein, free detergent, precipitant,
lipids....), their interactions (association state, solvation weak interparticle
interactions) and capacity of the membrane proteins to crystallize. Neutron
scattering and analytical ultracentrifugation combined with specific deuterium
labelling will be used in order to distinguish detergent and protein
components. Different membrane transporters involved on the transport of drugs
will be studied.</span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt'> </span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span lang=EN-GB
style='font-size:12.0pt'>Among other possibilities, the subject is proposed by
the International PhD program of the Life Sciences (DSV) of the <i><span
style='font-style:italic'>Commissariat ŕ l’Energie Atomique</span></i>
(CEA) (deadline for on line application: Mars 8th 2008: <a
href="http://www-dsv.cea.fr/en/phd-program">http://www-dsv.cea.fr/en/phd-program</a>).
</span></font><span lang=EN-US>Start of the thesis contract: October 2008. Duration:
three years. The gross annual salary is between 18300 and 23000 Euros.</span></p>
<p class=MsoNormal><font size=3 color=navy face="Times New Roman"><span
lang=EN-GB style='font-size:12.0pt;color:navy'> </span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Contact : Christine Ebel, </span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>Laboratoire de Biophysique Moléculaire, Institut de Biologie
Structurale,</span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>41 rue Jules Horowitz, f-38027 Grenoble, France. </span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><a href="mailto:christine.ebel@ibs.fr">christine.ebel@ibs.fr</a></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><a
href="http://www.ibs.fr/content/ibs_eng/presentation/lab/lbm/ebel.htm">http://www.ibs.fr/content/ibs_eng/presentation/lab/lbm/ebel.htm</a></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p class=MsoNormal><font size=2 face="Courier New"><span style='font-size:10.0pt;
font-family:"Courier New"'>Christine EBEL</span></font></p>
<p class=MsoNormal><font size=2 face="Courier New"><span style='font-size:10.0pt;
font-family:"Courier New"'>Institut de Biologie Structurale CEA-CNRS-UJF</span></font></p>
<p class=MsoNormal><font size=2 face="Courier New"><span style='font-size:10.0pt;
font-family:"Courier New"'>41 rue Jules Horowitz, F-38027 Grenoble France</span></font></p>
<p class=MsoNormal><font size=2 face="Courier New"><span style='font-size:10.0pt;
font-family:"Courier New"'>Tel (33) (0) 4 38 78 95 70; Fax (33) (0) 4 38 78 54
94 </span></font></p>
<p class=MsoNormal><font size=2 face="Courier New"><span style='font-size:10.0pt;
font-family:"Courier New"'>christine.ebel@ibs.fr</span></font></p>
<p class=MsoNormal><font size=2 color=navy face="Courier New"><span lang=EN-GB
style='font-size:10.0pt;font-family:"Courier New";color:navy'><a
href="http://www.ibs.fr/content/ibs_eng/presentation/lab/lbm/ebel.htm"><font
color=navy><span lang=FR style='color:navy'>http://www.ibs.fr/content/ibs_eng/presentation/lab/lbm/ebel.htm</span></font></a></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'> </span></font></p>
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