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<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><FONT size=3><FONT
face=Arial>Dear <?xml:namespace prefix = st1 ns =
"urn:schemas-microsoft-com:office:smarttags" /><st1:PersonName
w:st="on">RASMB</st1:PersonName>ers:<?xml:namespace prefix = o ns =
"urn:schemas-microsoft-com:office:office" /><o:p></o:p></FONT></FONT></P>
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<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><FONT size=3><FONT face=Arial>We
are writing to announce the release of HETEROANALYSIS, which is a new integrated
software package designed to facilitate studies of complex macromolecular
interactions by sedimentation equilibrium. The package, along with an extensive
help file, can be downloaded from our facility
website:<o:p></o:p></FONT></FONT></P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><SPAN
style="COLOR: windowtext"><FONT face=Arial size=3><A
href="http://www.biotech.uconn.edu/auf/?i=aufftp">http://www.biotech.uconn.edu/auf/?i=aufftp</A></FONT></SPAN></P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><FONT
face=Arial></FONT> </P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><FONT size=3><FONT face=Arial>The
helpfile is also available online at the same site.<o:p></o:p></FONT></FONT></P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><o:p><FONT face=Arial
size=3> </FONT></o:p></P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><FONT face=Arial><FONT
size=3>HETEROANALYSIS<SPAN class=206495913-01092005> </SPAN>incorporates an
intuitive graphical user interface and integrates data loading, editing,
analysis and simulation of sedimentation equilibrium experiments. The editing
module is similar to the earlier WinNonlin</FONT><SPAN
style="FONT-SIZE: 10pt"> </SPAN><FONT size=3>program for data trimming and
deglitching. The analysis portion features both single species and a range of
self- and hetero-association fitting models, including models that incorporate
thermodynamic nonideality and incompetent species. The software accommodates
multi-wavelength and multi-signal data and features a convenient function to
“link” data channels. The text and graphical output are integrated into a
logfile that can be output in rich text format.<SPAN
style="mso-spacerun: yes"> </SPAN>The data simulation module allows
users to create multi-signal synthetic data for each of the fitting models to
aid in experimental design and to validate fitting procedures.<SPAN
style="mso-spacerun: yes"> </SPAN>Finally, the loaded data, fitting
parameters, graphs and the log file can be saved to a compressed experiment file
and reloaded at a later time.<o:p></o:p></FONT></FONT></P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><o:p><FONT face=Arial
size=3> </FONT></o:p></P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><FONT face=Arial><FONT
size=3>HETEROANALYSIS runs under WinXP, Win2000 and </FONT><SPAN
style="FONT-SIZE: 10pt"> </SPAN><FONT size=3>Win9X.
<o:p></o:p></FONT></FONT></P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><o:p><FONT face=Arial
size=3> </FONT></o:p></P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><FONT size=3><FONT face=Arial>We
hope you find the program useful.<SPAN style="mso-spacerun: yes">
</SPAN><o:p></o:p></FONT></FONT></P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><o:p><FONT face=Arial
size=3> </FONT></o:p></P>
<P class=MsoNormal style="MARGIN: 0in 0in 0pt"><FONT size=3><FONT face=Arial>Jim
Cole and Jeff Lary<o:p></o:p></FONT></FONT></P></FONT></DIV></BODY></HTML>