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<DIV>One problem I have with these discussions is they are method of analysis
focused and until Arthur's illustion to "know your system" not focused on the
molecules, the mechanism, the interactions. Were we just talking about one
run and one concentration or a series of conectrations? Why do you want to
integrate? Are the "peak" positions constant or do they change with
concentration? Is this in fact an impure system of nointeracting species
or aggregates, or are these aggregates of a single component? Is there any
reversible interaction going on?</DIV>
<DIV> </DIV>
<DIV>The goal is to describe your system in molecular and mechanistic terms
and then fit the data individually & globally to that model to prove the
hypothesized mechanism. Statistics, assumptions, simulations are all
important. Now what is going on in your system? </DIV>
<DIV> </DIV>
<DIV>-------------------------------------------------------------------<BR> Dr.
John J. "Jack" Correia<BR> Department of Biochemistry<BR> University
of Mississippi Medical Center<BR> 2500 North State Street<BR> Jackson,
MS 39216<BR> (601)
984-1522
<BR> fax (601)
984-1501
<BR> email address: <A
href="mailto:jcorreia@biochem.umsmed.edu">jcorreia@biochem.umsmed.edu</A>
<BR> homepage location: <A
href="http://biochemistry.umc.edu/correia.html">http://biochemistry.umc.edu/correia.html</A><BR> dept
homepage location: <A
href="http://biochemistry.umc.edu/">http://biochemistry.umc.edu/</A><BR>-------------------------------------------------------------------<BR> <BR> <BR></DIV></BODY></HTML>