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<tt><font face="Courier New, Courier" size=2>June 23, 2004<br>
To: All Analytical Ultracentrifuge Users, Past, Present and
Future<br>
</font> <br>
<font face="Courier New, Courier" size=2>From: Aviv Biomedical, on behalf
of the Center to Advance Molecular Interaction Science (CAMIS),
University of New Hampshire<br>
</font> <br>
<font face="Courier New, Courier" size=2>Regarding: Survey to Gauge
Interest in Advanced Optics for Beckman Coulter Analytical
Ultracentrifuges<br>
</font> <br>
<font face="Courier New, Courier" size=2>The Request: <br>
CAMIS feels that it would be beneficial to gauge the level of interest in
a Rapid Scan Absorbance Accessory. Therefore a survey has been
written with the intention of including the results in an instrumentation
grant proposal. Please take a few minutes to complete the following
survey BEFORE 1 JULY 2004 and return it to Dr. Glen Ramsay,
<a href="mailto:glen@avivbiomedical.com">glen@avivbiomedical.com</a>.<br>
</font> <br>
<font face="Courier New, Courier" size=2>Background: <br>
CAMIS, in conjunction with the Biomolecular Interactions Technologies
Center (BITC) at the University of New Hampshire, has developed a new
laser-based fluorescence detection accessory to be used in the Beckman
Analytical Ultracentrifuges. This system is completing its final
tests and is now being released to beta sites. Its capabilities
extend the sensitivity and selectivity of the instrument, allowing
measurements that until now have been impossible. Under agreement with
CAMIS and BITC, Aviv Biomedical is commercializing the accessory.
<br>
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<font face="Courier New, Courier" size=2>The Project:<br>
CAMIS is now planning its future projects. One of them is to
develop a Rapid Scan Absorbance upgrade for the Beckman Coulter XLA/XLI
instruments. The upgrade would include: <br>
* Faster data collection: data for all samples collected in a single
rotation; samples scanned simultaneously, not sequentially. <br>
* Modern software: improved data handling ability; contemporary user
interface; support for the recently developed data analysis software;
21CRF11 compliance; automation of calibration and control of detector and
light source; log files<br>
* Reproducible wavelength measurements<br>
* Simultaneous operation with the fluorescence detection accessory:
allowing marked reductions in experiment time and sample consumption;
improves the correlation between the different measurement modes,
allowing smaller variations to be more easily detected.<br>
* Replacement of the existing light source while keeping the optics
inside the chamber.<br>
</font> <br><br>
<font face="Courier New, Courier" size=2>Instructions: If your email
client copies the original message when you hit “REPLY”, do so. Then go
through the email and answer the questions. Hit “SEND”.<br>
If your email client does not copy the original message when you
reply, please highlight the survey and copy it to your reply. Go through
and fill it out. Hit “SEND”.<br>
PLEASE make sure that the reply is NOT addressed to RASMB.<br>
<br><br>
*** Rapid Scan Absorbance Accessory Survey ***<br>
<br>
1) Have you used analytical ultracentrifugation? <br>
a) Past
User
Yes[ ] No[ ]<br>
b) Present
User
Yes[ ] No[ ]<br>
c) Future
User
Yes[ ] No[ ]<br><br>
2) What is the nature of your research? Select all that apply and/or
write in your choice below. <br>
Physical chemistry of biological
molecules [ ]<br>
Protein-nucleic acid
interactions
[ ]<br>
Drug-nucleic acid
interactions
[ ]<br>
Thermodynamics of biological
molecules [
]<br>
Kinetics of macromolecular
systems
[ ]<br>
Affinity
analysis
[ ]<br>
Other (define)
___________________________________________<br><br>
3) Where does your work take place?<br>
Academic/medical school research
lab
[ ]<br>
Pharmaceutical/biotech drug discovery
R&D [ ]<br>
Pharmaceutical/biotech drug formulation
QC [ ]<br><br>
4) Location of your laboratory<br>
United States, Canada, Central or South America [ ]<br>
Great Britain,
Europe
[ ]<br>
India, Asia,
Australia
[ ]<br>
Other (define) _________________________________<br><br>
5). Which types of detectors have you used?<br>
a)
Absorbance
Yes[ ] No[ ]<br>
b)
Interference
Yes[ ] No[ ]<br>
c)
Turbidity
Yes[ ] No[ ]<br>
d)
Schlieren
Yes[ ] No[ ]<br>
e)
Fluorescence
Yes[ ] No[ ]<br>
f) Other _______________________ <br><br>
6). What types of detectors do you plan on using or would like to
use?<br>
a)
Absorbance
Yes[ ] No[ ]<br>
b)
Interference
Yes[ ] No[ ]<br>
c)
Turbidity
Yes[ ] No[ ]<br>
d)
Schlieren
Yes[ ] No[ ]<br>
e)
Fluorescence
Yes[ ] No[ ]<br>
f) Other
________________________________________________<br><br>
7) How would the availability of a Rapid Scan Absorbance Accessory
benefit your research? What needs have not been met with the
present optical system?<br>
Speed
[ ]<br>
Sensitivity
[ ]<br>
Resolution
[ ]<br>
Data
analysis
[ ]<br>
Other (define)
______________________________________________________<br>
<br>
8) If a Rapid Scan Absorbance Accessory were available would it be in
your budget <br>
to pay for a service lab to make measurements for you (assuming current
market prices)?<br>
Yes[ ] No[ ]<br>
<br>
9) If a Rapid Scan Absorbance Accessory were commercially available would
it be in your budget to purchase it?<br>
Yes[ ] No[ ]<br>
<br>
10)Please fill in additional comments that you feel are appropriate:
__________________________________________________________<br>
__________________________________________________________<br><br>
Name:<br>
Institution:<br>
Mailing Address:<br>
Telephone:<br>
Fax:<br>
Email:<br>
<br>
This email has been sent by Aviv Biomedical, Inc., <br>
750 Vassar Avenue, Lakewood,NJ 08701. <br>
Tel 732-370-1300. Fax 732-370-1301 <br>
Email:avivbiomedical@aol.com <br>
Website:
<a href="http://www.AvivBiomedical.com">www.AvivBiomedical.com</a><br><br>
<br>
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