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<DIV><FONT size=2>Hello all</FONT></DIV>
<DIV><FONT size=2>the latest version of COVOL is now downloadable from the ncmh
software page, (the zipped file comes with readme instructions and a
pdf of a related paper).</FONT></DIV>
<DIV><FONT size=2>The new version COVOL3 runs from a Windows 98 or<BR>XP
environment, and predicts the 2nd virial coefficient B (exclusion volume and
charge terms) from user supplied values of the triaxial dimensions or axial
ratios (from e.g. crystal structure), molecular weight, vbar, hydration, valency
and ionic strength.</FONT></DIV>
<DIV><A
href="http://www.nottingham.ac.uk/ncmh/unit/method.html#Software">http://www.nottingham.ac.uk/ncmh/unit/method.html#Software</A></DIV>
<DIV> </DIV>
<DIV>It is helpful if you want to knock out the B term when dealing with
molecular associations.</DIV>
<DIV>The simple MSTAR routine (model independent estimation of molecular weights
from sedimentation equilibrium) can also now be downloaded from this
page (complementing the more advanced ORIGIN version of Kristian Schilling
and the model dependent NONLIN).</DIV>
<DIV>For those still interested in simple ellipsoid modelling of solution
protein conformation (as opposed to the advanced bead models of Jose et alia)
the ELLIPS suite of algorithms (ELLIPS1 for ellipsoid of revolution and
ELLIPS2-4 for triaxials (with 2 unequal axial ratios) - all involving full
solution of the elliptical integrals rather than approximate formulae) will also
be downloadable in 98 & XP forms from that page shortly.</DIV>
<DIV>Steve</DIV>
<DIV> </DIV>
<DIV>----------------------------------------------------------------------------------<BR>Professor
S.E. Harding<BR>NCMH Physical Biochemistry Laboratory<BR>University of
Nottingham<BR>School of Biosciences<BR>Sutton Bonington <BR>LE12 5RD, UK<BR>Tel:
+44(0) 115-951-6148<BR>Fax: +44(0) 115-951-6142<BR><A
href="http://www.nottingham.ac.uk/biosciences/foodsci/academic/harding.html">http://www.nottingham.ac.uk/biosciences/foodsci/academic/harding.html</A>
<BR>---------------------------------------------------------------------------------</DIV>
<DIV> </DIV>
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