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<div style="text-align: center;"><big><span
style="font-weight: bold;">Request for Proposals<br>
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<div style="text-align: right;"><small><span
style="font-style: italic;">Posted March 2003</span></small><br>
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<br>
The Biomolecular Interaction Technologies Center (BITC) at the
University of New Hampshire is soliciting research proposals for funding.<br>
<br>
BITC is a National Science Foundation Industry/University Cooperative
Research Center established to carry out research in coordination with
pharmaceutical and biotechnology companies. For general information
about BITC, its member companies, and a list of funded projects, go to
the Web site: <a href="http://www.bitc.unh.edu">www.bitc.unh.edu</a>.<br>
<br>
Research proposals should deal with methods based preferably on first
principles that can be used to quantitate the binding interaction
between molecular species, specifically protein-protein interactions
(including monoclonal antibodies), protein-nucleic acid interactions,
small molecule drug-protein interactions and drug-lipid interactions.
The development of new instruments or methods, or the refinement of
existing equipment or techniques, will be considered. The objective
should be the use of the instrument or method on a routine basis for
either molecular screening or as an analytical technique in research
relevant to drug discovery or development. <br>
<br>
Areas of interest: 1) high-throughput binding assays; 2) more robust
software for data acquisition analysis; and 3) improved methods for
characterizing binding of membrane proteins. Technologies of particular
interest to pharmaceutical researchers include but are not restricted
to: atomic force microscopy, fluorescence spectroscopy, total internal
reflection fluorescence spectroscopy, high-throughput calorimetry,
surface plasmon resonance, coupled wavelength plasmon resonance,
analytical electrophoresis, analytical ultracentrifugation, light
scattering, circular dichroism, mass spectrometry, and nuclear magnetic
resonance spectroscopy.<br>
<br>
Researchers at academic institutions are eligible to apply. Proposals
are accepted from outside the U.S.; however, the principal investigator
must be a U.S. citizen and the research must be conducted within the
U.S. Awards range from $15,000 to $100,000 per year; project duration is
typically two years. <br>
<br>
Submit a one-page preproposal via email as either an RTF or Word
document, or as a PDF. Preproposals must include a description of the
project, estimated cost, duration, and credentials of the principal
investigator. Preproposal submission deadlines: May 1 and November 1.
Email to: Dr. Thomas M. Laue, <a href="mailto:bitc.unh@unh.edu">bitc.unh@unh.edu</a>.<br>
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style="vertical-align: top; text-align: left; font-weight: bold;">Preproposal<br>
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<td style="vertical-align: top; font-weight: bold;">Selected<br>
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<td style="vertical-align: top; font-weight: bold;">Invitation<br>
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<td style="vertical-align: top; font-weight: bold;">Proposal<br>
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<td style="vertical-align: top; font-weight: bold;">Receipt<br>
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<td style="vertical-align: top; font-weight: bold;">Preproposal<br>
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<td style="vertical-align: top; font-weight: bold;">To
Submit</td>
<td style="vertical-align: top; font-weight: bold;">Receipt<br>
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<td style="vertical-align: top; font-weight: bold;">Funding<br>
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<td style="vertical-align: top; font-weight: bold;">Dates<br>
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<td style="vertical-align: top; font-weight: bold;">Review<br>
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<td style="vertical-align: top; font-weight: bold;">Full
Proposal<br>
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<td style="vertical-align: top; font-weight: bold;">Dates<br>
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<td style="vertical-align: top; font-weight: bold;">Decision<br>
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<td style="vertical-align: top;">May 1<br>
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<td style="vertical-align: top;">July<br>
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<td style="vertical-align: top;">August<br>
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<td style="vertical-align: top;">October 1<br>
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<td style="vertical-align: top;">January<br>
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<td style="vertical-align: top;">November 1<br>
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<td style="vertical-align: top;">January<br>
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<td style="vertical-align: top;">February<br>
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<td style="vertical-align: top;">April 1<br>
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<td style="vertical-align: top;">July<br>
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