[RASMB] [EXTERNAL] Serum and EH&S

[Susumu UCHIYAMA]

Dear John,

Yes, our AUC is placed in BS-L1 level room.

Best regards,
Susumu




On 2018/09/28 5:39, John Sumida wrote:
>
> Dear Susumu,
>
> Thank you for your response.  Interesting that your facility does 
> accept third party testing of human serum samples.  I will be meeting 
> with our EH&S group next week and this information together with 
> John’s will be helpful.  I assume that you are running your AUC under 
> standard BS-L1 conditions, and that it is sufficient for you to show 
> that your samples have been tested for blood borne pathogens?
>
> Once again, thank you for taking the time to respond to my question.
>
> Best regards,
>
> John Sumida
>
> University of Washington.
>
> *From:*RASMB [mailto:rasmb-bounces at list.rasmb.org] *On Behalf Of 
> *Susumu UCHIYAMA
> *Sent:* Thursday, September 27, 2018 12:34 PM
> *To:* rasmb at list.rasmb.org
> *Subject:* Re: [RASMB] [EXTERNAL] Serum and EH&S
>
> We also run AUC of proteins in serum using commercial human and murine 
> serum (ref attached). Commercial human serum is usually tested for 
> infectious material before selling but it might need higher level of 
> bio-safety if you use serum from patients.
> As for serum from health volunteer, it depends on the guideline of the 
> organization.
>
> I guess AUC has filter not HEPA but "BioSafe optional dual PALL 
> Pharmaceutical-Grade Sterilizing Filters" which is installed for 
> preparative UC at the vacuum exhaust.
>
> Best,
> Susumu
>
>
>     *From:* RASMB [mailto:rasmb-bounces at list.rasmb.org] *On Behalf Of
>     *John Sumida
>     *Sent:* Wednesday, September 26, 2018 5:00 PM
>     *To:* RASMB <rasmb at list.rasmb.org> <mailto:rasmb at list.rasmb.org>
>     *Subject:* [EXTERNAL] [RASMB] Serum and EH&S
>
>     Dear RASMB,
>
>     I apologize that this is not a scientific question, but this is,
>     perhaps, a question that has come up for some on the list and I
>     would be curious to hear how it was handled.
>
>     We periodically field requests to spin human serum solutions,
>     which invariably is a health & safety problem due to the potential
>     for a cell leak and the subsequent aerosolization of a potentially
>     hazardous material into the lab environment.
>
>     As an academic lab, our resources and institutional motivation in
>     engineering a space specific for this application are limited. 
>     Thus, one suggestion was to use third party testing of samples
>     being submitted for analysis.  However this is costly and most
>     users have abandoned their efforts to perform these measurements
>     as a result.
>
>     I would be curious to know if third party testing of potentially
>     infectious materials such as human serum is commonly used within
>     an EH&S setting, or if it is possible to place a HEPA filter in
>     the vacuum exhaust if the instrument uses a TMP?
>
>     Thank you in advance for any information you may be able to offer.
>
>     Best regards
>
>     John Sumida
>
>     University of Washington.
>
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