[RASMB] AUC Interlaboratory Comparison for Nanomaterial Definition

Wendel Wohlleben wendel.wohlleben at basf.com
Mon Jun 19 12:41:37 PDT 2017


Dear all, over the last two years, the JRC and BASF fine-tuned the same prep and analysis of (nano)particles for AUC. Please help to demonstrate (June to August) the validity of the AUC technique by participating in the interlab comparison !! The effort is limited.
If interested, reply still this week to ana.boix-sanfeliu at ec.europa.eu<mailto:ana.boix-sanfeliu at ec.europa.eu> and me in CC.

Mit freundlichen Grüßen // best regards,
Wendel

Wendel Wohlleben
Senior Scientist: Characterization of Nanomaterials
Material Physics

Phone: +49 621 60-95339 Mobile: +49 173 3797703 Fax: +49 621 60-92281 E-Mail: wendel.wohlleben at basf.com<mailto:wendel.wohlleben at basf.com>
Postal Address: BASF SE, GMC/R - B7, 67056 Ludwigshafen, Germany

BASF - We create chemistry

BASF SE, Registered Office: 67056 Ludwigshafen, Germany
Registration Court: Amtsgericht Ludwigshafen, Registration No.: HRB 6000
Chairman of the Supervisory Board: Juergen Hambrecht
Board of Executive Directors:
Kurt Bock, Chairman; Martin Brudermueller, Vice Chairman; Hans-Ulrich Engel, Sanjeev Gandhi, Michael Heinz, Harald Schwager, Wayne T. Smith, Margret Suckale


From: KOEBER Robert (JRC-GEEL)
Sent: Tuesday, May 23, 2017 11:58 AM
Subject: Nanomaterial Definition Interlaboratory Comparisons



Call for participation in a series of interlaboratory validation studies for the assessment of a quantitative nanomaterial definition


Geel, 23rd May 2017


Introduction
The European Commission (EC) published in 2011 a Recommendation on the definition of the term nanomaterial to determine whether a material should be considered as nanomaterial for regulatory purposes[1]. Nanomaterial is defined as "a natural, incidental or manufactured material containing particles, in an unbound state or as an aggregate or as an agglomerate and where, for 50% or more of the particles in the number size distribution, one or more external dimensions is in the size range 1 – 100 nm". The proper implementation of this definition triggered the need for developing and validating characterisation and quantification methodologies for nanomaterials.
In the frame of the FP7 Project NanoDefine[2] and under the auspices of Technical Working Area (TWA) 34 of VAMAS (Versailles project on Advanced Materials and Standards)[3]; the European Commission's Joint Research Centre (JRC) will organize a series of independent interlaboratory comparisons (ILCs) of methods in support to the implementation of EC Recommendation 211/696/EU.

Objectives
The major objective of the ILCs is to assess the fitness for purpose of the methods to  determine whether 50% of the particles in a particulate material are smaller than 100 nm. Number-based and mass-based size distributions will be monitored depending on the measurement method. Between-laboratory reproducibility of the methods will be assessed.
If the ILCs indicate that the results of the methods are reproducible, then the methods could be offered to ISO and/or CEN for standardisation.

Work programme
Participants are invited to join one, or multiple, of the following interlaboratory comparisons:


1)    Electron microscopy
Participants will be requested to use an ImageJ script to derive number based size distributions based on pre-recorded TEM images. The ImageJ plugin provides different splitting methods to handle agglomerates and aggregates, robust handling of different noise levels and adaptability to non-standard images.


2)    Centrifugal liquid sedimentation (CLS)
Participants will be allowed to use one of three types of CLS instruments:
- cuvette-analytical centrifuge with optical detection,
- line-start disc centrifuge with optical detection, or
- analytical centrifuge with refractive index detection
For each technique, a specific protocol for the sample preparation and measurement of two grades of BaSO4 samples will be provided.


3)    Single particle ICP-MS:
Three specific protocols for the sample preparation and measurement of three samples (TiO2 particles in suspension, TiO2 particles in sunscreen, and Al2O3 particles in toothpaste) will be provided.


4)    Field Flow Fractionation coupled to ICP-MS:
A specific protocol for the sample preparation and measurement of TiO2 particles in sunscreen by AF4-MALS-ICP-MS will be provided.

General outline of the exercise
The collaborative trials are opened to participants that are expert in the field of analysis of nanomaterials using methods based on the analytical techniques listed above. Participants are invited to join one or more ILCs and fund their own involvement in this exercise. Please feel free to forward this call to competent colleagues that might be interested to join this exercise.

The JRC will provide each participant with the necessary samples and the detailed analytical protocols per ILC. Since the aim of this exercise is to assess the performance of the methods (not of the laboratory), the protocols provided for each ILC must be strictly followed.
The set-up and execution of the collaborative studies will be done according to ISO 17043. Samples will be dispatched in June 2017 and the results should be reported in August 2017.

Expression of interest
The laboratories are kindly asked to register for taking part in the exercise by email by 9 June 2017 at the latest. Please send a message to ana.boix-sanfeliu at ec.europa.eu with the subject “Nanomaterial Definition Interlaboratory Comparisons” and clearly indicate:

-      Your institution name

-      The name and surname of the contact person

-      The complete postal address where the samples should be dispatched

-      A contact telephone number

-      A contact email address
These details will only be used for the dispatch of the materials and for any further correspondence.


For more information:



Dr. Ana BOIX

Joint Research Centre, EC, Belgium ana.boix-sanfeliu at ec.europa.eu<mailto:ana.boix-sanfeliu at ec.europa.eu>

Dr. Robert KOEBER

Joint Research Centre, EC, Belgium robert.koeber at ec.europa.eu<mailto:robert.koeber at ec.europa.eu>



[1] Commission Recommendation of 18 October 2011 on the definition of nanomaterial, Official Journal of the European Union 2011/696/EU:38-40.

2 NanoDefine. Development of an integrated approach based on validated and standardized methods to support the implementation of the EC recommendation for a definition of nanomaterial. European Union’s Seventh Programme for research, technological development and demonstration, grant agreement No 604347-2. http://www.nanodefine.eu<http://www.nanodefine.eu/>

3 Versailles Project on Advanced Materials and Standards (VAMAS). http://www.vamas.org



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Directorate General Joint Research Centre
Directorate F – Health, Consumers and Reference Materials

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Joint Research Centre: The European Commission's science and knowledge service
Discover JRC Science Hub: https://ec.europa.eu/jrc
and our Reference Materials: http://referencematerials.eu<http://referencematerials.eu/>

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The views expressed are purely those of the writer and may not in any circumstances be regarded as stating an official position of the European Commission.


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[1] Commission Recommendation of 18 October 2011 on the definition of nanomaterial, Official Journal of the European Union 2011/696/EU:38-40.

[2] NanoDefine. Development of an integrated approach based on validated and standardized methods to support the implementation of the EC recommendation for a definition of nanomaterial. European Union’s Seventh Programme for research, technological development and demonstration, grant agreement No 604347-2. http://www.nanodefine.eu<http://www.nanodefine.eu/>

[3] Versailles Project on Advanced Materials and Standards (VAMAS). http://www.vamas.org


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