[RASMB] Empty voids

[Tom Laue]

Hi-
There was some work done on this by, I believe, Don Caspar-
Caspar, D. L. D. and Badger, J. (1991) "Plasticity of Crystalline 
Proteins." Curr. Opin. Struct. Biol. I, 877-882
Yu, B., Blaber, M., Gronenborn, A. M., Clore, G. M. and Caspar, D. L. D. 
(1999) "Disordered Water Within a Hydrophobic Protein Cavity Visualized 
by X-ray Crystallography." Proc. Natl. Acad. Sci. USA, 96, 103-108.
Adamek, D.H., Guerrero, L., Blaber, M., and Caspar, D. L. D. (2005) 
"Structural and energetic consequences of mutations in a solvated 
hydrophobic cavity." J. Mol. Biol., 346, 307-318.
Best to all-
Tom

Dj Scott wrote:
>
> Hello all in RASMB-land.
>
> A question for you.
>
>  
>
> If I make a void in a protein by mutating a larger residue to a 
> smaller one in the hydrophobic core, what is the thermodynamic cost of 
> this, and how would it be best to measure it.
>
>  
>
> All thoughts welcome.
>
> Best
>
>  
>
> Dave.
>
> >>>>>>>>>>>>>>>>>>>>>>>>>>
> Dr. David J. Scott
> Associate Professor in Physical Biochemistry
> National Centre for Macromolecular Hydrodynamics
> School of Biosciences
> University of Nottingham
> Sutton Bonington Campus
> Leicestershire. LE12 5RD.
> United Kingdom.
> Phone: +44 (0) 115 951 6221
> Fax: +44 (0) 115 951 6142
> Email: dj.scott at nottingham.ac.uk
> Web: www.nottingham.ac.uk/ncmh
>
>  
>
>
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-- 
Department of Biochemistry and Molecular Biology
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