[RASMB] Empty voids

[Chad Brautigam]

Hi Dave,

I'm no expert, but wouldn't DSC address this?  Also, I haven't studied  
up on this in a while, but Brian Matthews' lab did some research on  
void filling in lysozyme.  There might be some answers therein.

Chad

======================================
Chad A. Brautigam, Ph.D.
Assistant Professor
Department of Biochemistry
The University of Texas
Southwestern Medical Center at Dallas
Department of Biochemistry
5323 Harry Hines Blvd.
Rm. ND10.214A
Dallas, TX 75390-8816
Office:  214-645-6384
Fax:  214-645-6353
Email:  chad.brautigam at utsouthwestern.edu





On Jun 3, 2010, at 11:08 AM, Dj Scott wrote:

> Hello all in RASMB-land.
> A question for you.
>
> If I make a void in a protein by mutating a larger residue to a  
> smaller one in the hydrophobic core, what is the thermodynamic cost  
> of this, and how would it be best to measure it.
>
> All thoughts welcome.
> Best
>
> Dave.
> >>>>>>>>>>>>>>>>>>>>>>>>>>
> Dr. David J. Scott
> Associate Professor in Physical Biochemistry
> National Centre for Macromolecular Hydrodynamics
> School of Biosciences
> University of Nottingham
> Sutton Bonington Campus
> Leicestershire. LE12 5RD.
> United Kingdom.
> Phone: +44 (0) 115 951 6221
> Fax: +44 (0) 115 951 6142
> Email: dj.scott at nottingham.ac.uk
> Web: www.nottingham.ac.uk/ncmh
>
>
>
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