[RASMB] Empty voids

[Dj Scott]

Hello all in RASMB-land.

A question for you. 

 

If I make a void in a protein by mutating a larger residue to a smaller
one in the hydrophobic core, what is the thermodynamic cost of this, and
how would it be best to measure it.

 

All thoughts welcome.

Best

 

Dave.

>>>>>>>>>>>>>>>>>>>>>>>>>> 
Dr. David J. Scott 
Associate Professor in Physical Biochemistry 
National Centre for Macromolecular Hydrodynamics 
School of Biosciences 
University of Nottingham 
Sutton Bonington Campus 
Leicestershire. LE12 5RD. 
United Kingdom. 
Phone: +44 (0) 115 951 6221 
Fax: +44 (0) 115 951 6142 
Email: dj.scott at nottingham.ac.uk 
Web: www.nottingham.ac.uk/ncmh 

 

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