[RASMB] Urea diffusion and sedimentation coefficient (further)

[Arthur Rowe]

Greetings everyone

(and especially those interested in the rather obscure topic of the
diffusion coefficient of urea)

Further to my earlier mail (below), two further things to be added:

(1) I am much indebted to Dr Trushar Patel for mailing me a reference to a
paper from a more 'classical' age which gives values for the diffusion
coefficient of urea (and a range of other solutes) at temperatures from 1º
to 37º :

L G Longsworth (1954) "Temperature dependence of diffusion in aqueous
solutions" J Phys Chem 58 770-773


(2) I have found a very recent publication (June 2007) which explores the
issue by molecular dynamics, and comes to the conclusion that at the urea
levels commonly used for protein denaturation, urea is about 20% is dimeric:

Stump & Grubmüller (2007) J Phys Chem B 111 6220-6228

Arthur


--
*******************************************************
Arthur J Rowe
Professor of Biomolecular Technology
NCMH Business Centre
University of Nottingham
School of Biosciences
Sutton Bonington
Leicestershire LE12 5RD   UK

Tel:        +44 (0)115 951 6156
          +44 (0)116 271 4502
Fax:        +44 (0)115 951 6157
email:      arthur.rowe at nottingham.ac.uk
Web:        www.nottingham.ac.uk/ncmh/business
*******************************************************





Hello All
Does anyone have to hand the diffusion and sedimentation coefficient for
Urea?
cheers

dave.

Dr. David J. Scott
Lecturer in Physical Biochemistry
National Centre for Macromolecular Hydrodynamics
School of Biosciences
University of Nottingham
Sutton Bonington Campus
Sutton Bonington
Leicestershire
LE12 5RD
United Kingdom
dj.scott at nottingham.ac.uk
www.nottingham.ac.uk/ncmh
+44 (0) 115 951 6221 Phone
+44 (0) 115 951 6142 Fax

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