[RASMB] looking for a nice validation system
Allen Minton
minton at helix.nih.gov
Thu Jun 28 06:07:54 PDT 2007
Greetings -
We are trying to validate a new system for rapid characterization of
reversible macromolecular heteroassociations and are looking for a
nice 1-1 associating pair of macromolecules that have similar MWs
(within a factor of 2). The association constant should be between
10^4 and 10^8 M^-1 under specified conditions. Oh, yes, the
reactants should be commercially available and not too expensive, as
we are going to need a few mg of each.
Anybody out there have suggestions? References to prior studies of
these associations would be greatly appreciated.
Allen Minton
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