[RASMB] MacNonlin for OS X (or anything close)

[Peter Schuck]

Dear RASMB,

for those working in the Windows environment, there's also the possibility 
to fit sedimentation equilibrium (self-association and hetero-associations, 
global analysis, multi-wavelength, Monte-Carlo analysis, noise 
decomposition etc.) with SEDPHAT.   This has been significantly extended 
over the two last years.

The software can be downloaded from
http://www.analyticalultracentrifugation.com/sedphat/sedphat.htm
where there's also detailed help system.  Some of the new capabilities for 
sedimentation equilibrium have been described recently in Analytical 
Biochemistry
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15003564

Peter

P.S. Regarding Borries' comment about Ultrascan sedimentation velocity 
analysis, I'm not completely sure how much similarity the Mw distributions 
of Ultrascan really have with the c(s) distributions in SEDFIT.




At 08:19 AM 4/12/2004 -0500, you wrote:
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> > Dear RASMB,
> >
> > Is there a relatively current version of MacNonlin out there? All I've
> > been able to find is the OS7-era version, the link to which doesn't
> > even appear to be active. I've been processing XL-A sedimentation
> > equilibrium data on a series of related constructs for about a year
> > now, mostly by hand (loving the Excel Macros)--but that's only going to
> > go so far when it comes to trying to fit multiple self-associations.
> > Unix would even be fine--anything besides the Windows version?
> >
> > Reba Howard
>
>Reba,
>
>You and others interested in platform alternatives for sedimentation
>analysis should take a look at UltraScan.
>
>UltraScan has a full-featured global fitting module for equilibrium
>experiments, whith built-in extinction coefficient correction for fitting
>of unlimited number of speeds, loading concentrations and wavelengths
>scans. You can choose from several fitting algorithms such as Levenberg
>Marquardt, Quasi Newton and Gauss Newton. There is also a nonnegatively
>constrained general least squares fitter for obtaining MW distributions
>similar in concept to the C(s) distributions from Peter Schuck's velocity
>analysis program. You can select from a number of predefined nonlinear
>models and define your own models as well. It also has a built in
>presentation graphics module similar to Origin to create publication
>quality graphs.
>
>I should also mention that UltraScan has a Monte Carlo module for
>statistical analysis of your fitting results. When used in the Unix
>environment, UltraScan offers a Beowulf Cluster module that allows you
>to perform the Monte Carlo analysis on many machines in parallel.
>This option is not available in the Microsoft Windows port, although
>you can still use the Monte Carlo analysis on a single Windows machine.
>If the computer has multiple processors, the multi-threaded fitter will
>take advantage of it, and you can run multiple Monte Carlo instances on
>an SMP machine, even with the Windows version.
>
>UltraScan is available for Intel Linux, Mac Linux PPC, Sparc Linux,
>Microsoft Windows, SGI Irix, and we now have a beta version for Mac OSX
>(needs some tweaking for a successful installation). It can be
>downloaded for free for academic use from http://www.ultrascan.uthscsa.edu
>Support is also available.
>
>Documentation is avalable on the web:
>
>Experimental design considerations:
>http://www.ultrascan.uthscsa.edu/tutorial/equil_tutorial.html
>
>Nonlinear least squares fitter:
>http://www.ultrascan.uthscsa.edu/manual/nls.html
>
>Global nonlinear least squares analysis with UltraScan:
>http://www.ultrascan.uthscsa.edu/manual/equil1.html
>
>Let me know if you need addtl. information.
>
>Regards, -Borries
>---
>Borries Demeler, Ph.D.
>The University of Texas Health Science Center at San Antonio
>Dept. of Biochemistry, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900
>Voice: 210-567-6592, Fax: 210-567-4575, Email: demeler at biochem.uthscsa.edu
>
>
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