[RASMB] frctional ratio

[Steve Shire]

But if the formula weight is based on amino acid composition this is 
still a possibility. Does this protein have putative N-glycosylation 
sites?
               Steve
On Friday, June 27, 2003, at 05:40  AM, Arthur Rowe wrote:

> Peter -
>
> Agreed, glyco stuff can be 'floppy', and increase friction. However, 
> in the present case, given that the mass estimated by SLS (41.4 kD) 
> agrees well with (what I take to be) the formula weight (41.7 kD), it 
> is not too likely to be an explanation, is it ?
>
> Arthur
>
> Ewa and Arthur,
> there's also a possibility that the frictional ratio could be quite 
> high if
> the protein is glycosylated.  In my experience, that can increase the
> friction quite a bit.
> Peter
>
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>
>
Steven J. Shire, Ph.D.
Staff Scientist and Group Leader
Pharmaceutical Research and Development Dept.
MS #96A
Genentech, Inc.
1 DNA Way
S. San Francisco, CA 94080
650-225-2077 (VOICE)
650-225-7234 (FAX)
sh
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